Exploration of the decontamination of common nonmetallic materials by Ce(IV)/HNO3.

With the rapid development of the nuclear medicine business worldwide, the removal of iodine-131 from specific contaminated environments to protect public health has important application prospects. In this study, the surface decontamination mechanism of Ce(IV)/HNO3 as a decontaminant for iodine-131-contaminated nonmetallic materials was investigated by using an orthogonal experimental method and scanning electron microscopy (SEM). During the preparation experiments with the contaminated materials, both quartz glass and ceramics reached peak activity concentration levels at 4 h of adsorption (contamination) by using immersion; the decontamination factor (DF) was selected as the test index for the decontamination experiments.

Methods used in early value assessments for nice: a scoping review.

Objectives: The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs and contribute to the National Health Service's Long Term Plan. However, there are currently no published works considering differences and commonalities in methods used between Assessment Reports for EVAs.

Methods: This rapid scoping review included all completed EVAs published on the NICE website up to 23 July 2024.

Innovations in cardiac regenerative medicine: The role of tissue engineering.

Cardiovascular disease (CVD) is a leading cause of death worldwide. CVD includes conditions such as myocardial infarction (MI), arrhythmias, valvular heart disease, and cardiomyopathy. The limitations of heart treatment are related to the inability of damaged cells to regenerate, which leads to an increasing demand for new therapies.

CRISPR/Cas9-Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production.

N-Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N-glycosylated proteins, but their use is impeded by the presence of plant-specific N-glycan epitopes, which raise concerns of possible immunogenicity to humans. In this study, N-glycoengineered Nicotiana benthamiana plants that produce more homogeneous N-glycans without plant-specific epitopes were generated using multiplex CRISPR/Cas9 genome editing.

Use of shunt-side esCCO monitoring for hemodynamic management during hemodialysis as a novel approach for early detection of hypotension: a report of two cases.

Early recognition of the signs of hypotension may lead to prompt intervention by medical professionals, reducing the risk of intradialytic hypotension. The study included two patients on dialysis, one with stable hemodynamics (Case 1) and one who developed hypotensive shock (Case 2), in whom noninvasive continuous hemodynamic monitoring using shunt-side estimated continuous cardiac output (esCCO) was performed. Noninvasive blood pressure (BP), heart rate, esCCO, estimated stroke volume, systemic vascular resistance, and decrease in blood volume of each patient before and after dialysis were evaluated in chronological order.

Storage cabinet design and infection prevention implications for long endoscopes.

Background: Adequate drying of endoscope channels following reprocessing is critical to inhibit microbial growth. This study evaluated residual moisture and bacterial contamination in endoscopes stored using different cabinets and storage methods.

Methods: EN-580T endoscopes were stored in three cabinets: TJ-908S and TJ-804S (both with active drying) and TM-804S (passive drying).

Monte Carlo study of the eye lens exposure of medical staff administering Sc-47 and Cu-67 labelled radiopharmaceuticals.

Purpose: In the last decades, new technologies and new radiopharmaceuticals for diagnosis and therapy have continuously grown, and that growth was accompanied by an increasing use in clinical practice, but, as with any other application involving radiation, the extent to which they may contribute to increasing the radiation dose to the operator must be studied. For that reason, EURADOS (European Radiation Dosimetry Group) decided to evaluate the exposure of medical staff in nuclear medicine to new possible radiopharmaceuticals labelled with Sc-47 and Cu-67.

Methodology: Modified ICRP voxel model were employed to determine the exposure of the eye lens and of the thyroid of operators administrating radiopharmaceuticals in a typical Peptide Receptor Radionuclide Therapy scenario.

Attribute-Based Medicine for IgA Nephropathy: Risk Factor Constellations Influence Kidney Prognosis.

Background And Hypothesis: Attribute-based medicine emphasizes tailoring care to patient-specific characteristics. IgA nephropathy (IgAN), a heterogeneous glomerular disease, presents varying risks across subgroups. We hypothesized that an attribute-based medicine approach could identify residual risk factors and inform personalized strategies.

Relation knowledge distillation 3D-ResNet-based deep learning for breast cancer molecular subtypes prediction on ultrasound videos: a multicenter study.

Background: To develop and test a relation knowledge distillation three-dimensional residual network (RKD-R3D) model for predicting breast cancer molecular subtypes using ultrasound (US) videos to aid clinical personalized management.

Methods: This multicentre study retrospectively included 882 breast cancer patients (2375 US videos and 9499 images) between January 2017 and December 2021, which was divided into training, validation, and internal test cohorts. Additionally, 86 patients was collected between May 2023 and November 2023 as the external test cohort.

Difference in Microembolic Signals Between Flex-Tip Versus Non-Flex-Tip Type Catheters During High-Power Short-Duration Ablation.

Introduction: A novel flex-tip ablation catheter has a distal tip with a unique design, especially for optimized irrigation flow against catheter contact. This study aimed to evaluate the microembolic signals (MESs) during high-power short-duration (HPSD) ablation between flex-tip and non-flex-tip catheters.

Method And Results: We retrospectively evaluated 70 patients (39 and 31 with flex-tip and non-flex-tip catheters, respectively) who underwent first-time HPSD radiofrequency ablation with a 50 W-power setting for atrial fibrillation at two institutions.

Association of exposure below various thresholds of hemodynamic parameters during cardiopulmonary bypass with acute kidney injury.

Introduction: This study aimed to investigate the association of exposure below various thresholds of mean arterial pressure (MAP), pump flow rates, and hemoglobin levels during cardiopulmonary bypass (CPB) with cardiac surgery-associated acute kidney injury (CSA-AKI).

Methods: Adult patients undergoing cardiac surgery with CPB at a university hospital between April 2015 and August 2023 were included. The primary outcome was CSA-AKI within 7 days postoperatively.

Sorbitol-responsive in situ gel improves rat ischemic hearts: Supporting mesenchymal stem cell survival and enhancing paracrine effect.

Mesenchymal stem cells (MSCs) repair damaged myocardium by secreting biological factors and have shown only modest therapeutic efficacy in clinical trials. We recently developed a sorbitol-responsive in situ gelling material (SRG) solution, which increases viscosity by diffusing out pre-added sorbitol upon contact with heart tissue without external stimulation. Here, this study demonstrates that intramyocardial injection of MSC-loaded SRG (MSC/SRG) improves cardiac function and facilitates tissue repair following acute myocardial ischemia in rats, and the underlying mechanisms are elucidated.

Characteristics of Effective Antitachycardia Pacing for Ventricular Tachycardia: The Importance of True Septal Lead Position.

Background: Antitachycardia pacing (ATP) has a potential benefit for shock reduction of implantable cardioverter-defibrillator (ICD) recipients; however, its clinical utility and characteristics are unknown.

Objectives: This study aims to extract characteristics leading to a high ventricular tachycardia (VT) termination rate of ATP.

Methods: Patients who had a history of ≥1 ATP treatment episode from ICD or cardiac resynchronization therapy-defibrillator (CRTD) devices were included.

base-excision restriction enzyme in stomach carcinogenesis.

Many recent lines of evidence from the human microbiome and other fields indicate bacterial involvement in various types of cancer. has been recognized as the major cause of stomach cancer (gastric cancer), but the mechanism by which it destabilizes the human genome to cause cancer remains unclear. Our recent studies have identified a unique family of toxic restriction enzymes that excise a base (: adenine) from their recognition sequence (5'-GTC).

Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification.

Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain. In this study, using newly generated Slc20a2 knockout (Slc20a2) mice, we establish an in vivo model for PBC. In contrast to heterozygous Slc20a2 mice (9/9 animals) showing no obvious abnormalities, the homozygous Slc20a2 mice exhibited severe calcification at 11 months of age (5/5 animals).

Safe Continuation of Apheresis during Pregnancy using the Double-Filtration Plasmapheresis Thermo Mode in a Pregnant Female with Familial Hypercholesterolemia: A Case Report.

Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated LDL cholesterol levels and an increased risk of early-onset atherosclerotic cardiovascular disease. In pregnant female with FH, apheresis is the preferred treatment because standard therapeutic agents such as statins are contraindicated during pregnancy. LDL adsorption therapy is commonly used; however, after 27 weeks of gestation, it is often switched to dual filtration plasma exchange (DFPP) due to the significant drop in blood pressure caused by bradykinin production.

Refractory Atrial Tachyarrhythmias Management in Severely Dilated Right Atrium Due to Complex Congenital Heart Disease: Clinical Perspectives Beyond Catheter Ablation.

Refractory atrial tachyarrhythmias frequently occur in patients with congenital heart disease (CHD) who have a markedly enlarged right atrium (RA). To elucidate arrhythmogenic substrates and evaluate the comprehensive treatment outcomes in patients with complex CHD and a giant RA (≥190 mL). Ten patients with complex CHD and a giant RA who underwent catheter ablation (CA) were evaluated (median age, 40 [interquartile range (IQR), 33 to 52] years).

Utility and feasibility of intra-pocket mapping technique for optimal subcutaneous implantable cardioverter defibrillator implantation positioning for R-wave detection: a case series.

Background: A subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to a conventional transvenous implantable cardioverter defibrillator for preventing sudden cardiac death. Although posterior chest S-ICD implantation has been recommended for better defibrillation outcomes, little is known about the optimal S-ICD positioning for R-wave detection. Herein, we report two cases of S-ICD recipients in whom antero-inferior chest positioning improved R-wave detection after posterior chest positioning failed.

Better together: biomimetic nanomedicines for high performance tumor therapy.

The emergence of nanotechnology offers a promising avenue for enhancing cancer treatment outcomes. In this context, biomimetic nanoparticles have emerged as an exciting frontier in the field of biomedicine. These nanoparticles can emulate essential biological functions, drawing from an abundant reservoir of cellular capabilities.

Clinical Utility of the Rotational and Orbital Atherectomy System in the Endovascular Therapy of Severely Calcified Femoropopliteal Lesions.

Background: Endovascular therapy (EVT) for severely calcified femoropopliteal (FP) lesions in patients with peripheral artery disease (PAD) is challenging. This study evaluates the clinical utility of rotational atherectomy and orbital atherectomy in EVT for such lesions.

Methods And Results: This single-center retrospective study enrolled 62 consecutive patients with symptomatic PAD (71.

Vagal blockade of the brain-liver axis deters cancer-associated cachexia.

Cancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearly one-third of cancer-related deaths. It contributes to therapy resistance and increases mortality among affected patients. In this study, we show that cancer-induced systemic inflammation alters vagal tone in CAC mouse models.

GS1 and RFID Integration for Enhanced Medical Device Traceability in Catheterisation Laboratories.

This study presents a novel system that integrates GS1 barcodes and radio frequency identification (RFID) technology with the objective of enhancing the medical device traceability in catheterization laboratories. The necessity for precise tracking of medical devices, particularly in the context of cardiovascular procedures is underscored by the occurrence of sporadic product recalls. Despite the existence of traceability systems, no solution has effectively combined GS1 and RFID technologies to ensure precise tracking throughout the clinical process.

Continuous Kidney Replacement Therapy and Outcomes of Severe Coronavirus Disease 2019 Treated With Extracorporeal Membrane Oxygenation.

Introduction: Although continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI) management is common, its effect on the outcomes of patients treated with extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) remains unclear. Therefore, we aimed to investigate the impact of CKRT on the outcomes of these patients.

Methods: Using a database of patients with severe COVID-19 who required venovenous ECMO across three centers in Japan, we assessed demographics, clinical parameters, and in-hospital mortality rates from January 2020 to December 2021.