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In this work, we report a complete response case of a 69-year-old male with metastatic prostate cancer (initial prostate-specific antigen (PSA)=26.3 ng/mL, Gleason score 3+4=7, cT3a, N0, M1b) treated with triplet therapy comprising leuprorelin + docetaxel (75 mg/m/3 weeks) + darolutamide (1,200 mg/d). His PSA was checked monthly, and radiological scans (computed tomography and bone scans) were administered every three months. His PSA declined quickly, reaching <0.01 ng/mL five months after starting triplet therapy, but his bone scan index declined gradually, reaching 0.0% 13 months after starting triplet therapy. To evaluate the true efficacy of triplet therapy, regular radiological testing should be performed, similar to regular PSA testing.
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http://dx.doi.org/10.7759/cureus.81642 | DOI Listing |
Anat Sci Educ
September 2025
University of Florida College of Medicine, Gainesville, Florida, USA.
Self-efficacy and anatomical knowledge have been shown to be important in the development of medical students. Validated instruments designed to measure the construct of anatomical self-efficacy during the clinical years of medical school are limited. In this study, the Anatomical Self-Efficacy Instrument for Clinical Clerkships (ASEI-CC) was developed, and evidence for the reliability of the scores and the validity of the interpretations of the scores was gathered.
View Article and Find Full Text PDFFertil Steril
September 2025
REI Division, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Carver College of Medicine, Iowa City. Iowa. 52242.
Objective: To investigate the impact of objectively measured physical activity and stress on programmed hormone replacement therapy (HRT) frozen embryo transfer (FET) outcomes.
Design: Observational cohort study SUBJECTS: Patients undergoing standard HRT FET at a single academic center.
Exposure: Average daily step counts before and after FET as measured by FitBit Charge 5 wearable activity tracker.
Biochimie
September 2025
Immunopathology and Viral Reservoir Unit, National Center of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; Biomedical Research Center Network in Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
TLR8 and TLR9 are innate immune receptors belonging to the TLR family that are essential for viral recognition and early immune activation. Their dysfunction is linked to increased susceptibility to infections. TLR8 detects viral single- and double-stranded RNA, while TLR9 recognizes viral DNA molecules with CpG motifs.
View Article and Find Full Text PDFCell Rep Med
August 2025
Department of Thoracic Surgery, Shanghai Key Laboratory of Thoracic Tumor Biotherapy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Shanghai Institute of Thoracic Oncology, Shanghai 200030, China. Electronic address:
The diagnostic accuracy of circulating tumor DNA (ctDNA) for detecting molecular residual disease (MRD) after multimodal treatment remains unclear. In a prospective cohort of 132 patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoradiotherapy (nCRT) followed by clinical response evaluation and surgery, tumor-informed personalized-panel and fixed-panel ctDNA assays are applied to serial blood samples. Personalized ctDNA assay demonstrates a superior baseline detection rate (99.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
September 2025
Department of Dermatology and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
Purpose: Tebentafusp has emerged as the first systemic therapy to significantly prolong survival in treatment-naïve HLA-A*02:01 + patients with unresectable or metastatic uveal melanoma (mUM). Notably, a survival benefit has been observed even in the absence of radiographic response. This study aims to investigate the feasibility and prognostic value of artificial intelligence (AI)-assisted quantification and metabolic response assessment of [F]FDG long axial field-of-view (LAFOV) PET/CT in mUM patients undergoing tebentafusp therapy.
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