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Article Abstract
Transition-metal-free transformations are recognized as green and sustainable methods for constructing carbon-carbon bonds in organic synthesis. This review describes the application of six organic peroxides, including -butyl hydroperoxide (TBHP), di--butyl peroxide (DTBP), -butyl peroxybenzoate (TBPB), benzoyl peroxide (BPO), dialauroyl peroxide (DLP), and diguyl peroxide (DCP), in C-C bond construction, highlighting selected examples and mechanisms of challenging transformations. Each section concludes with a detailed overview of suitable reagents for various coupling reactions and strengths and weaknesses of the reported works. This work aims to inspire further innovations in transition-metal-free oxidative transformations, promoting sustainable and eco-friendly chemical processes and paving the way for new peroxide-based organic synthesis methods.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044487 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c11574 | DOI Listing |
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