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In this work, a charge plasma TMD heterojunction tunnel FET-based dielectrically modulated biosensor is designed and investigated for biosensing applications. In the proposed biosensor, WTe and MoS serve as the source and channel material, respectively to form the heterojunction. Whereas the channel-drain junction is a homojunction formed by MoS. The advantage of heterojunction has been exploited to overcome the low I and ambipolar behavior of TFET, which results in the enhancement of sensitivity. The charge plasma doping has been utilized to mitigate random dopant variations, reduce manufacturing expenses, and simplify the fabrication process. Non-equilibrium green's function (NEGF)-based simulator and SILVACO TCAD, a 2-D device simulator have been utilized to simulate the electrical characteristics of the proposed biosensor. Uniform filling of the cavities in biosensors is not always practically possible; thus, the issue of partial hybridization is also considered in this work. The proposed biosensor (for k = 9) achieves a high sensitivity of 10, an I/I ratio of 10, and a low subthreshold swing of 39 mV/decade. Finally, the proposed biosensor is benchmarked with contemporary works of the literature and it has been observed that the presented charge plasma TMD heterojunction TFET (CP-TMD-HJ-TFET)-based biosensor has emerged to have a superior sensitivity (i.e. I/I ratio) which is ∼ 4 decades higher than the maximum sensitivity reported by any contemporary biosensor.
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http://dx.doi.org/10.1038/s41598-024-84677-6 | DOI Listing |
Biosens Bioelectron
September 2025
UCD Centre for Biomedical Engineering, University College Dublin, Belfield, Dublin, 4, Ireland; School of Mechanical & Materials Engineering, University College Dublin, Belfield, Dublin, 4, Ireland. Electronic address:
Surface electromyography (sEMG) is the measurement of the electrical activity of muscle and is extensively used in fundamental research and across many applications in health and sport. Conventional surface electrode technology can suffer from poor signal quality, particularly when used outside the laboratory, requires careful skin preparation prior to electrode application, and can be challenging when used for long-term recording. These limitations have challenged the translation of sEMG to widespread clinical application.
View Article and Find Full Text PDFPest Manag Sci
September 2025
National Pesticide Engineering Research Center, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, People's Republic of China.
Background: Rapid advances in generative artificial intelligence (AI) are accelerating the process of pesticide development. However, transfer learning-based de novo design focuses on generating molecules that are highly similar to existing inhibitors, which may limit the exploration of novel scaffolds and thereby constrain innovative breakthroughs in pesticide development.
Results: This study proposes a new strategy for fungicide design using antibiotics.
Anal Chem
September 2025
Institute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China.
Compared with efficient anodic luminol electrochemiluminescence (ECL), the disadvantage of cathodic ECL is that luminol cannot be electrochemically oxidized in a direct manner, and the conversion efficiency of dissolved oxygen (DO) as the coreactant to reactive oxygen species (ROS) is poor, which limits its application. Therefore, it is necessary to develop a functional catalyst suitable for the luminol-DO ECL system to directly trigger cathodic ECL. In this study, a coordination microenvironment modulation strategy was proposed.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Chemical Engineering, Jashore University of Science and Technology Jashore 7408 Bangladesh
Bacterial detection is crucial for accurate clinical diagnostics and effective environmental monitoring. Particularly, , a pathogenic bacterium, can cause a wide range of infections, including meningitis, bloodstream infections, pneumonia, urinary tract infections, and wound or surgical site infections. Herein, a polypyrrole (PPy) functionalized TiCT -tin dioxide nanoparticle (SnO NPs) nanocomposite-based hybrid capacitive electrode for the electrochemical detection of ATCC 700603 is developed.
View Article and Find Full Text PDFAnalyst
September 2025
Functional Nanomaterial-based Chemical and Biological Sensing Technology Innovation Team of Department of Education of Yunnan Province, Yunnan Minzu University, Kunming 650504, P. R. China.
Copper ions are essential elements in the human body and participate in various physiological activities in the bodies of organisms. Herein, an ultrasensitive electrochemical biosensor was developed for detection of copper ions (Cu) based on FeO@Au magnetic nanoparticles (FeO@Au MNPs) and a Cu-dependent DNAzyme assisted nicking endonuclease signal amplification (NESA) strategy. dsDNA is formed by a hybridization reaction between DNA S2 and S1 immobilized on the surface of FeO@Au MNPs.
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