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Semiconducting nanomaterials have been widely explored for various applications due to their remarkable coordination between electronic and morphological attributes. The extent of their potential applications transcends from various environmental remediation applications like sensing and photocatalysis to several complex applications like energy storage/production and drug delivery processes. The properties of semiconducting nanomaterials can be effectively tuned by changing the solvent strategies. A solvent can effectively interfere in the nucleation process and hence can significantly influence the shape and size of nanomaterials, which is directly related to other important properties. In this review article, we have holistically discussed and categorized different solvents and encompassed their role in the preparation strategies of different semiconducting nanomaterials. We have tried to explain the evolution of solvent strategies based on the reported literature, that is the evolution from conventional solvents to more advanced and nascent solvent strategies like ionic liquids and deep eutectic solvents. After adequate comparison, we have concluded that the change or rather advancements in the solvent strategies have dramatically enhanced and transformed the properties and potential of several semiconducting nanomaterials in the domains such as photocatalysis, sensing, biomedical and electrochemical applications. We anticipate that this review article will encourage researchers across the globe to explore and develop novel solvent strategies and assess their effect on the properties of different classes of materials.
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http://dx.doi.org/10.1016/j.cis.2025.103524 | DOI Listing |
Org Lett
September 2025
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
The synthesis of tirzepatide relies heavily on solid phase peptide synthesis (SPPS), a process that is both costly and time-consuming. In this paper, a novel soluble liquid-phase assisted (LPPS) strategy for the efficient synthesis of tirzepatide is presented. The efficacy of the method is based on the distinct solubility properties of the soluble tag, which enables high yield synthesis while significantly reducing wastage of amino acids and solvents.
View Article and Find Full Text PDFNanoscale
September 2025
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Precious metal nanomaterials have demonstrated significant advantages in the field of alcohol electro-catalytic oxidation. In this study, the inexpensive main group metals lead (Pb) and platinum (Pt) have been innovatively selected to construct an alloy catalyst. By employing the solvent-thermal method, PtPb nanoparticles with a well-defined crystalline structure were successfully synthesized, exhibiting excellent performance.
View Article and Find Full Text PDFJ Mass Spectrom
October 2025
Department of Chemistry and Technology of Drugs, "Sapienza" University of Rome, Rome, Italy.
Ionic liquids (ILs) are a class of organic salts with melting points below 100°C. Owing to their unique chemical and physical properties, they are used as solvents and catalysts in various chemical transformations, progressively replacing common volatile organic solvents (VOCs) in green synthetic applications. However, their intrinsic ionic nature can restrict the use of mass spectrometric techniques to monitor the time progress of a reaction occurring in an IL medium, thus preventing one from following the formation of the reaction products or intercepting the reaction intermediates.
View Article and Find Full Text PDFInt J Pharm X
June 2025
Medical School, Southeast University, Nanjing 210009, China.
This study aimed to create multifunctional nanoparticles (NPs), specifically AS1411@MPDA-Len-Cy5.5 (AMLC), for the purpose of developing effective strategies for treating hepatocellular carcinoma (HCC) through targeted therapy and photothermal therapy (PTT). The study involved synthesizing mesoporous polydopamine (MPDA)-NPs, loading lenvatinib (Len) and Cy5.
View Article and Find Full Text PDFACS Electrochem
September 2025
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
The study of electrochemical oxidations has wide-ranging implications, from the development of new electrocatalysts for fuel cells for energy conversion, to the synthesis of fine chemicals. 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) has been used for decades as a sustainable, metal-free mediator for chemical oxidations and is now being used for electrochemical oxidations. We describe here a novel approach to TEMPO-mediated electrooxidations, in which the chemical input and waste generated during electrooxidations of alcohols are minimized by using a multifunctional room temperature ionic liquid (RTIL) to facilitate flow electrosynthesis.
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