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Article Abstract
Purpose: To experimentally evaluate the change in radial diffusivity with diffusion time ( ) as a simple estimate of axon diameter.
Methods: Ex vivo ferret spinal cords were imaged via MRI and scanning electron microscopy. Region-of-interest comparisons were made between and area-weighted mean axon diameter, , derived from scanning electron microscopy. Additional comparisons were made between and quantitative MRI myelin metrics.
Results: A strong linear correlation was found between and . Negative correlations were found between myelin water fraction and as well as bound pool fraction and .
Conclusion: The value of is shown to be a good estimate of axon size in ex vivo spinal cords regardless of variations in myelin content, as indicated by quantitative MRI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202731 | PMC |
| http://dx.doi.org/10.1002/mrm.30538 | DOI Listing |
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