Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Psychomotor impairments due to alcohol consumption may lead to a series of negative consequences. However, the influence of sex and polymorphism on psychomotor dysfunction has not yet been investigated.
Methods: One-hundred and three participants, genotyped for rs671, were administered a dose of 1.0 g/kg of white spirits. The blood ethanol concentration (BEC) and acetaldehyde concentration (BAAC) were measured at specific time intervals before and after alcohol consumption. Additionally, auditory simple reaction time (ASRT), visual choice reaction time (VCRT), pursuit tracking task (PTT) and digit-symbol substitution test (DSST) were used to evaluate psychomotor function. Linear mixed-effects model was used to analyze the effects of sex and the genotype on alcohol metabolism and psychomotor function..
Results: Acetaldehyde metabolism depended on both genotype and sex. Women with genotype exhibited 2.21 to 18.27 µmol/L higher BAAC levels than men with the same genotype. Conversely, among participants with genotype, BAAC levels of women were 0.25 to 31.32 µmol/L lower than men. The impact of genotype on psychomotor function varied across the four tests. VCRT increased significantly in men with genotype compared to those with at 2-4 h post-consumption. In the PTT test, the percentage of time on target decreased by 3.83% and 3.11% in women relative to men at 1 and 2 h post-consumption, respectively. Notably, ASRT performance was significantly correlated with BAAC levels. No effects of genotype and sex were observed on DSST performance.
Conclusions: genotype and sex independently or interactively contribute to alcohol-related psychomotor impairment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039403 | PMC |
| http://dx.doi.org/10.1080/07853890.2025.2496798 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
First Identification of a Novel HIV-1 CRF80_0107/B Recombinant Form Among Men Who Have Sex with Men in Hebei Province, China.
AIDS Res Hum Retroviruses
September 2025
Clinical Laboratory, The People's Hospital of Baoding, Baoding, China.
The emergence of CRF80_0107 resulted from recombination between co-circulating CRF01_AE and CRF07_BC genotypes. To date, no secondary recombinants involving CRF80_0107 as a parental strain have been documented in public sequence databases. Here, we report the identification and characterization of a novel HIV-1 CRF80_0107/B recombinant form isolated from a treatment-naïve men who have sex with men (MSM) individual in Baoding City, Hebei Province, China.
View Article and Find Full Text PDFIntergenerational continuity of depressive symptoms: genetic and environmental pathways.
Psychol Med
September 2025
Faculty of Behavioral and Social Sciences, Department of Pedagogy and Educational Sciences, https://ror.org/012p63287University of Groningen, Groningen, The Netherlands.
Background: Depression runs in families, with both genetic and environmental mechanisms contributing to intergenerational continuity, though these mechanisms have often been studied separately. This study examined the interplay between genetic and environmental influences in the intergenerational continuity of depressive symptoms from parents to offspring.
Methods: Using data from the Dutch TRAILS cohort ( = 2201), a prospective, genetically informed, multiple-generation study, we examined the association between parents' self-reported depressive symptoms (reported at mean age of 41 years) and offspring depressive symptoms, self-reported nearly two decades later, in adulthood (mean age: 29 years).
Molecular epidemiological analysis and investigation of antiretroviral drug resistance profile, including capsid inhibitors, among treatment-naïve individuals with HIV-1 in Türkiye.
HIV Med
September 2025
Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Introduction: Monitoring transmitted drug resistance is crucial for guiding first-line antiretroviral therapy (ART) and controlling the rising HIV epidemic in Türkiye. This study aimed to determine the prevalence of transmitted antiretroviral resistance to protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs) and capsid assembly inhibitors (CAIs). We also assessed the distribution of HIV-1 subtypes and circulating recombinant forms (CRFs) at one of the main national referral centres in Türkiye.
View Article and Find Full Text PDFEvidence for vertical transmission of avian reovirus in chickens.
Vet Microbiol
September 2025
College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Xinxing, Yunfu, Guangdong 527400, China. Electronic address:
Avian reovirus (ARV) has emerged as a highly prevalent pathogen in Chinese poultry, characterized by its high mutation rate, environmental resilience, and dual vertical-horizontal transmission routes, leading to rising chick morbidity and substantial economic losses. To evaluate vertical transmission, 945 dead embryos and 58 weak chicks from a Guangdong hatchery between January 2023 and December 2024 were tested, yielding a 9.6 % (96/1003) ARV positivity rate.
View Article and Find Full Text PDFRegular non-steroidal anti-inflammatory drug (NSAID) use increases stress fracture risk, but the mechanisms remain unclear. Here, we used Ptgs2-Y385F mice, which lack cyclooxygenase 2 (COX2) enzyme activity, to test the hypothesis that naproxen decreases strain adaptive bone remodeling in a COX2-dependent manner and decreases bone toughness and fracture resistance through COX2-independent effects. MicroCT and mechanical testing showed minimal baseline differences between Ptgs2-Y385F and wild-type (WT) mice.
View Article and Find Full Text PDF