Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

This study aims to address the clinical needs of hemiplegic and stroke patients with lower limb motor impairments, including gait abnormalities, muscle weakness, and loss of motor coordination during rehabilitation. To achieve this, it proposes an innovative design method for a lower limb rehabilitation training system based on Bayesian networks and parallel mechanisms. A Bayesian network model is constructed based on expert knowledge and structural mechanics analysis, considering key factors such as rehabilitation scenarios, motion trajectory deviations, and rehabilitation goals. By utilizing the motion characteristics of parallel mechanisms, we designed a rehabilitation training device that supports multidimensional gait correction. A three-dimensional digital model is developed, and multi-posture ergonomic simulations are conducted. The study focuses on quantitatively assessing the kinematic characteristics of the hip, knee, and ankle joints while wearing the device, establishing a comprehensive evaluation system that includes range of motion (ROM), dynamic load, and optimization matching of motion trajectories. Kinematic analysis verifies that the structural design of the device is reasonable, aiding in improving patients' gait, enhancing strength, and restoring flexibility. The Bayesian network model achieves personalized rehabilitation goal optimization through dynamic probability updates. The design of parallel mechanisms significantly expands the range of joint motion, such as enhancing hip sagittal plane mobility and reducing dynamic load, thereby validating the notable optimization effect of parallel mechanisms on gait rehabilitation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024597PMC
http://dx.doi.org/10.3390/biomimetics10040230DOI Listing

Publication Analysis

Top Keywords

parallel mechanisms
16
lower limb
12
rehabilitation
8
gait rehabilitation
8
rehabilitation training
8
bayesian network
8
network model
8
dynamic load
8
parallel
5
gait
5

Similar Publications

Prediction of microRNAs targeting oestrogen receptor beta: implications for emotional disorders.

Neuroscience

September 2025

Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Str., 02-106 Warsaw, Poland.

This review consolidates the most recent information regarding the role of microRNAs (miRNAs) that target the oestrogen receptor beta (ESR2/ERβ) gene in the pathophysiology of emotional disorders, with a particular emphasis on stress-related conditions and anxiety. Since in silico predictions frequently precede experimental validation and algorithms such as TargetScan and DIANA-microT identified possible miRNA binding sites on ESR2 based on sequence complementarity, we demonstrate a high degree of accuracy in predicting functional interactions. Parallel evidence unrelated to the studied biological contexts supports the idea that miRNAs may regulate ERβ signalling in emotional disorders, thereby further supporting miRNA-ESR2 interactions.

View Article and Find Full Text PDF

Source-specific insights into photochemical and microbial degradation of dissolved organic matter in coastal environments.

Mar Environ Res

September 2025

Shandong Key Laboratory of Coastal Environmental Processes, Yantai, Shandong, 264003, China.

Coastal zones are critical for the biogeochemical cycling of dissolved organic matter (DOM) in marine ecosystems, yet the relative importance of photochemical and microbial degradation in DOM transformation remains poorly understood due to complex hydrodynamics, diverse sources, and human activities. Through 14-day laboratory incubations, we investigated DOM transformation mechanisms from three common marine coastal space uses: port, mariculture and inshore areas adjacent to Yantai City. DOM characterization was performed using fluorescence excitation-emission matrix parallel factor (EEM-PARAFAC) and UV-Vis spectroscopic indices.

View Article and Find Full Text PDF

Control of intracellular pathogens is a critical element of host defense. Defining the molecular mechanisms by which the host restricts or eliminates these pathogens may inform the development of novel immunotherapeutics and antimicrobial strategies, particularly in the face of rising antibiotic resistance. In parallel, understanding how pathogens subvert these immune responses may yield new approaches to disrupt virulence rather than viability.

View Article and Find Full Text PDF

Metabolic interplay of SCFA's in the gut and oral microbiome: a link to health and disease.

Front Oral Health

August 2025

Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (deemed to be) University, Mangalore, India.

Short-chain fatty acids (SCFAs), primarily acetate (C2), propionate (C3), and butyrate (C4), are crucial microbial metabolites formed by the fermentation of dietary fibers by gut microbiota in the colon. These SCFAs, characterized by fewer than six carbon atoms, serve as an essential energy source for colonic epithelial cells and contribute approximately 10% of the body's total energy requirement. They are central to maintaining gut health through multiple mechanisms, including reinforcing intestinal barrier function, exerting anti-inflammatory effects, regulating glucose and lipid metabolism, and influencing host immune responses.

View Article and Find Full Text PDF

Exploring the effect of copper on the bioactivity of 8-quinolines: an and study.

Dalton Trans

September 2025

Biomedical Inorganic Chemistry Lab, Department of Chemical Sciences, University of Catania, v.le A. Doria 6, 95125, Catania, Italy.

Current anticancer therapy is challenged by the adaptability and resistance of tumor cells as well as limited drug selectivity that causes severe side effects. The scientific community maintains high interest in metal-based chemotherapeutic agents due to their unique interactions with cancer cells, potentially overcoming resistance mechanisms and exploiting the physiopathology of the tumour tissues. Copper, in particular, plays a dual role in cancer, both facilitating tumor progression and triggering cuproptosis, a copper-induced cell death mechanism.

View Article and Find Full Text PDF