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http://dx.doi.org/10.1007/s10620-025-09026-7 | DOI Listing |
Med Sci (Basel)
July 2025
Second Department of Cardiology, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Cardiac arrhythmias remain a major source of morbidity and mortality, often stemming from molecular and structural abnormalities that are insufficiently addressed by current pharmacologic and interventional therapies. Gene therapy has emerged as a transformative approach, offering precise and durable interventions that directly target the arrhythmogenic substrate. Across the spectrum of inherited and acquired arrhythmias-including long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, atrial fibrillation, and post-infarction ventricular tachycardia-gene-based strategies such as allele-specific silencing, gene replacement, CRISPR-mediated editing, and suppression-and-replacement constructs are showing growing translational potential.
View Article and Find Full Text PDFAnn Vasc Surg
August 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:
Background: Low-flow vascular malformations (LFVMs), encompassing venous, lymphatic, and capillary malformations, are congenital vascular anomalies marked by abnormal vascular or lymphatic development and low-flow hemodynamics. Sclerotherapy has become the primary treatment due to its minimally invasive nature and high efficacy. This review aims to outline the clinical applications, mechanisms, and outcomes of commonly used sclerosants for LFVMs.
View Article and Find Full Text PDFSensors (Basel)
August 2025
Department of Electrical and Computer Engineering, College of Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Anomaly detection in industrial imaging is critical for ensuring quality and reliability in automated manufacturing processes. While recently several methods have been reported in the literature that have demonstrated impressive detection performance on standard benchmarks, they necessarily rely on computationally intensive CNN architectures and post-processing techniques, necessitating access to high-end GPU hardware and limiting practical deployment in resource-constrained settings. In this study, we introduce a novel anomaly detection framework that leverages feature maps from a lightweight convolutional neural network (CNN) backbone, MobileNetV2, and cascaded detection to achieve notable accuracy as well as computational efficiency.
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
August 2025
Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea.
Bone defects resulting from trauma, disease, or congenital abnormalities present formidable clinical challenges, necessitating advanced regenerative strategies. In this study, a novel bone tissue engineering approach utilizing the osteoinductive properties of collagen/hydroxyapatite (HA) hydrogels and the structural support provided by 3D-printed polylactic acid (PLA) scaffolds was investigated. Specifically, MG63 osteoblast-like cells were encapsulated within collagen/HA hydrogels formulated at an optimized 5:5 ratio and subsequently loaded into PLA lattices.
View Article and Find Full Text PDFZhonghua Nan Ke Xue
October 2024
Department of Andrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China.
Asthenozoospermia is one of the major causes of male infertility, with complex pathogenesis, which involves abnormalities in sperm morphology, signaling pathways, sperm motility-related energy metabolism, and other factors. Currently, extracellular vesicles (EV) in the seminal plasma have been found with a positive effect on the spermatogenic process by releasing such self-encapsulated molecules as DAN, RNA and proteins into target cells through direct fusion with the structure similar to the lipid bilayer on the surface, and thereby regulating their function. This article reviews the research progress in the pathogenesis of asthenozoospermia, aiming to provide some theoretical evidence for its further studies.
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