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Anomaly detection in industrial imaging is critical for ensuring quality and reliability in automated manufacturing processes. While recently several methods have been reported in the literature that have demonstrated impressive detection performance on standard benchmarks, they necessarily rely on computationally intensive CNN architectures and post-processing techniques, necessitating access to high-end GPU hardware and limiting practical deployment in resource-constrained settings. In this study, we introduce a novel anomaly detection framework that leverages feature maps from a lightweight convolutional neural network (CNN) backbone, MobileNetV2, and cascaded detection to achieve notable accuracy as well as computational efficiency. The core of our method consists of two main components. First is a PCA-based anomaly detection module that specifically exploits near-zero variance features. Contrary to traditional PCA methods, which tend to focus on the high-variance directions that encapsulate the dominant patterns in normal data, our approach demonstrates that the lower variance directions (which are typically ignored) form an approximate null space where normal samples project near zero. However, the anomalous samples, due to their inherent deviations from the norm, lead to projections with significantly higher magnitudes in this space. This insight not only enhances sensitivity to true anomalies but also reduces computational complexity by eliminating the need for operations such as matrix inversion or the calculation of Mahalanobis distances for correlated features otherwise needed when normal behavior is modeled as Gaussian distribution. Second, our framework consists of a cascaded multi-stage decision process. Instead of combining features across layers, we treat the local features extracted from each layer as independent stages within a cascade. This cascading mechanism not only simplifies the computations at each stage by quickly eliminating clear cases but also progressively refines the anomaly decision, leading to enhanced overall accuracy. Experimental evaluations on MVTec and VisA benchmark datasets demonstrate that our proposed approach achieves superior anomaly detection performance (99.4% and 91.7% AUROC respectively) while maintaining a lower computational overhead compared to other methods. This framework provides a compelling solution for practical anomaly detection challenges in diverse application domains where competitive accuracy is needed at the expense of minimal hardware resources.
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http://dx.doi.org/10.3390/s25154853 | DOI Listing |
JMIR Res Protoc
September 2025
Department of Urology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Background: Circumcision is a widely practiced procedure with cultural and medical significance. However, certain penile abnormalities-such as hypospadias or webbed penis-may contraindicate the procedure and require specialized care. In low-resource settings, limited access to pediatric urologists often leads to missed or delayed diagnoses.
View Article and Find Full Text PDFRev Bras Enferm
September 2025
Federal University of Ceará. Fortaleza, Ceará, Brazil.
Objective: to analyze predictors of inadequacy of prenatal care among postpartum women in a maternity hospital in Brazil.
Methods: cross-sectional study conducted from March 2020 to January 2021 with postpartum women from a maternity hospital in Brazil. Statistical analysis was performed using Pearson's chi-squared test and Poisson regression.
JAMA Cardiol
September 2025
Department of Cardiology, Inselspital University Hospital of Bern, University of Bern, Bern, Switzerland.
Importance: Right anomalous aortic origin of a coronary artery (R-AAOCA) is a rare congenital condition increasingly diagnosed with the growing use of cardiac imaging. Due to dynamic compression of the anomalous vessel, invasive fractional flow reserve (FFR) during a dobutamine-atropine volume challenge (FFR-dobutamine) is considered the reference standard. A reliable alternative method is needed to reduce extensive invasive testing, but it remains uncertain whether noninvasive imaging can accurately assess the hemodynamic relevance of R-AAOCA.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Cytogenetics and Molecular Genetics Lab, Pathology Unit, Medical Division (BARC Hospital), Bhabha Atomic Research Centre, Anushakti Nagar, Mumbai, India.
Background: Hearing loss (HL) is one of the most common congenital anomalies and is a complex etiologically diverse condition. Molecular genetic characterization of HL remains challenging owing to the high genetic heterogeneity. This study aimed to screen for potential disease-causing genetic variations in a cohort of Indian patients with congenital bilateral severe-to-profound sensorineural HL.
View Article and Find Full Text PDFJ Pediatr Hematol Oncol
September 2025
Children's Hospital of Michigan, Division of Hematology/Oncology.
Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder characterized by abnormalities in platelet aggregation, resulting from quantitative or qualitative defects in integrins αIIb and β3. Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only potentially curative therapeutic approach for severe GT. In this report, we present 2 children with GT that underwent successful allo-HSCT, along with 2008 to 2022 data from the Center for International Blood and Marrow Transplant Research and a summary of the existing literature providing further evidence that allo-HSCT can be a curative approach that prevents severe and life-threatening bleeding in GT.
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