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In this study, a novel tunable dopingless band-to-band tunneling mechanism based Leaky Integrate and Fire (LIF) neuron is proposed with a notable improvement in integration density and energy consumption. The forward transfer characteristics of Tunnel FET with sharp sub-threshold swing have been utilised to simulate the neural activity. The simulations performed using Atlas 2D software confirm that the proposed TFET can effectively replicate the spiking behavior of a biological neuron, eliminating the need for additional circuitry, in addition to offering tunable features. The proposed LIF neuron demonstrates significantly lower energy consumption, operating at just 144 aJ per spike. This energy efficiency is at least [Formula: see text] times lower than the single MOSFET-based neuron and [Formula: see text] times lower than TFET-based 1-transistor neurons reported in prior literature. This remarkable improvement is attributed to the underlying mechanism, which leverages tunneling and material engineering techniques. The proposed neuron has also been successfully investigated for the implementation of adaptable threshold logic functions (NOT, OR and AND). This offers a solution for the design of highly scalable and energy efficient threshold logic circuits for future neuromorphic computing systems. Lastly, we implement a multilayer SNN that confirms the image recognition ability of the proposed neuron with 92.1% accuracy.
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http://dx.doi.org/10.1038/s41598-025-93727-6 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou, China.
Aims: This study is to investigate the role of Endothelin-converting enzyme-like 1 (ECEL1) in neuropathic pain (NP).
Methods: The expression of ECEL1 was modulated by injecting adeno-associated virus 5 (AAV5) carrying Ecel1 shRNA or full-length Ecel1 into the dorsal root ganglion (DRG) of mice with a chronic constriction injury (CCI) model. Then, various nociceptive responses were evaluated.
Small
August 2025
SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon, 16419, South Korea.
Neuromorphic systems that emulate the information transmission of biological neural networks face challenges in their integration owing to the disparate features of neuron- and synapse-mimicking devices, leading to complex and inefficient system architectures. Herein, the study proposes a steep-switching nonvolatile field-effect transistor leveraging a CuInPS/h-BN/WSe heterostructure to enable reconfigurable neuron- and synapse-modes by electrostatically modulating the carrier density of the channel to control its Fermi level, thereby facilitating leaky-integrate-and-fire (LiF) neuron operation. In addition, an additional ferroelectric-gating effect enhances the chemical potential of the channel through interactions between ferroelectric dipoles and channel carriers, allowing LiF operation at a reduced operating bias condition.
View Article and Find Full Text PDFAdv Mater
August 2025
Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, P. R. China.
Implementing Leaky Integrate-and-Fire (LIF) neurons in hardware is poised to enable the creation of efficient, low-power spiking neural networks (SNNs). This is attributed to the ability of LIF neurons to mimic the rapid response and sensitivity of biological neurons, thereby reducing unnecessary computational resources. The fixed firing frequency of conventional LIF neurons limits their adaptability to complex, dynamic environments.
View Article and Find Full Text PDFNat Commun
August 2025
College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Spiking neural networks (SNNs) are biologically more plausible and computationally more powerful than artificial neural networks due to their intrinsic temporal dynamics. However, vanilla spiking neurons struggle to simultaneously encode spatiotemporal dynamics of inputs. Inspired by biological multisynaptic connections, we propose the Multi-Synaptic Firing (MSF) neuron, where an axon can establish multiple synapses with different thresholds on a postsynaptic neuron.
View Article and Find Full Text PDFFront Netw Physiol
July 2025
Department of Biology, University of Ottawa, Ottawa, ON, Canada.
Introduction: Periodic brain stimulation (PBS) techniques, either intracranial or non-invasive, electrical or magnetic, represent promising neuromodulatory tools for the treatment of neurological and neuropsychiatric disorders. Through the modulation of endogenous oscillations, PBS may engage synaptic plasticity, hopefully leading to persistent lasting effects. However, stabilizing such effects represents an important challenge: the interaction between induced electromagnetic fields and neural circuits may yield highly variable responses due to heterogeneous neuronal and synaptic biophysical properties, limiting PBS clinical potential.
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