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Saline-alkali stress and cold damage significantly impact the yield of . G proteins play a crucial role in plant resistance to abiotic stresses, and research on G proteins in (rapeseed) is still in its early stages. In this study, we employed bioinformatics tools to systematically investigate the basic physicochemical properties, phylogenetic relationships, distribution, gene structure, cis-regulatory elements, and expansion patterns of the gene family in . Additionally, reverse transcription polymerase chain reaction (RT-PCR) was used to analyze the response of the gene to salt and low-temperature stresses. Natural variations were found in the promoter region of . By conducting a promoter-driven luciferase (LUC) assay, the relationship between natural variations in the promoter and salt and cold tolerance was analyzed. Furthermore, the impact of these natural variations on flowering time, root length, and yield was explored using phenotypic data from a population. Our research results aim to provide insights into the function and molecular mechanisms of in , and to offer valuable genetic resources for molecular breeding to improve salt and low-temperature tolerance in .
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http://dx.doi.org/10.3390/plants14071145 | DOI Listing |
Genes Genomics
September 2025
Department of Clinical Laboratory, The First Affiliated Hospital of Guilin Medical University, Le Qun Road 15, Guilin, 541001, Guangxi, China.
Background: Lung cancer (LC) is the leading cause of cancer-related deaths globally. Genetic variants in mismatch repair (MMR) genes, such as MutS homolog 2 (MSH2), MutS homolog 6 (MSH6) and MutL homolog 1 (MLH1), may influence individual susceptibility and clinical outcomes in LC.
Objective: This study investigated the associations of genetic polymorphisms in MSH2, MSH6, and MLH1 with susceptibility and survival outcomes in lung cancer patients in the Guangxi Zhuang population.
Metab Brain Dis
September 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, Hubei, 430022, China.
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health. This study aimed to discern variances in plasma metabolic profiles between MDD sufferers and healthy counterparts. Additionally, we tracked the hospitalization journey of MDD patients to investigate the normalization of metabolic irregularities through conventional treatment in the form of self-control.
View Article and Find Full Text PDFAust Endod J
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
This study aimed to investigate the biomechanical impact of root canal anatomical variations and restoration techniques on endodontically treated mandibular second molars using finite element analysis. Five root morphologies were modelled: separated-rooted (S), fused-rooted with V-shaped (F-V), U-shaped (F-U) or Ω-shaped (F-Ω) radicular grooves and single-canal fused-rooted (F-O). Micro-CT scans were performed before and after endodontic instrumentation to generate the finite element models: intact teeth, post-and-core crowns with 2- to 3-mm ferrules and endocrowns with 3- to 4-mm pulp chamber extensions.
View Article and Find Full Text PDFGenetics
September 2025
Department of Computational Biology, Cornell University, Ithaca, NY 14853, USA.
Selective sweeps describe the process by which an adaptive mutation arises and rapidly fixes in the population, thereby removing genetic variation in its genomic vicinity. The expected signatures of selective sweeps are relatively well understood in panmictic population models, yet natural populations often extend across larger geographic ranges where individuals are more likely to mate with those born nearby. To investigate how such spatial population structure can affect sweep dynamics and signatures, we simulated selective sweeps in populations inhabiting a two-dimensional continuous landscape.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.
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