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Fetal cerebellum landmark detection is crucial for assessing fetal brain development. Although deep learning has become the standard for automatic landmark detection, most previous methods have focused on using 2D ultrasound or thick Magnetic Resonance Imaging (MRI). To improve accuracy, landmarks should be located on thin 3D MRIs. However, abnormal development, high noise, and fuzzy boundaries in 3D fetal brain images make traditional methods less effective for cerebellum landmark detection. To address this, we introduce the Anatomical Pseudo-label Guided Attention (APGA) network alongside a 3D MRI-based benchmark for fetal cerebellum landmark detection. During training, we use a shared encoder to extract image features and two decoders for landmark regression and anatomical pseudo-label segmentation. We design a Feature Decoupling Transformer (FDT) and embed it into the encoder to better calibrate the features for the two tasks. We only need the encoder, the FDT, and the landmark decoder during the inference phase. Extensive experiments on our proposed benchmark and out-of-domain test set have shown the effectiveness of our method. Our simulations also demonstrated that 3D biometrics are better than 2D biometrics.
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http://dx.doi.org/10.1109/JBHI.2025.3559702 | DOI Listing |
Cell Rep Methods
August 2025
Department of Biomedical Engineering and Computational Biology Program, OHSU, Portland, OR, USA; Knight Cancer Institute, OHSU, Portland, OR, USA. Electronic address:
We present UniFORM, a non-parametric, Python-based pipeline for normalizing multiplex tissue imaging (MTI) data at both the feature and pixel levels. UniFORM employs an automated rigid landmark registration method tailored to the distributional characteristics of MTI, with UniFORM operating without prior distributional assumptions and handling both unimodal and bimodal patterns. By aligning the biologically invariant negative populations, UniFORM removes technical variation while preserving tissue-specific expression patterns in positive populations.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Intracranial aneurysms (ICA) commonly occur in specific segments of the Circle of Willis (CoW), primarily, onto thirteen major arterial bifurcations. An accurate detection of these critical landmarks is necessary for a prompt and efficient diagnosis. We introduce a fully automated landmark detection approach for CoW bifurcations using a two-step neural networks process.
View Article and Find Full Text PDFCureus
August 2025
Orthodontics and Dentofacial Orthopaedics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.
Aim: This study aimed to statistically evaluate and compare the accuracy, reliability, and efficiency of manual versus artificial intelligence (AI)-assisted digital cephalometric tracing using Steiner's and Down's analyses in orthodontic diagnostics.
Materials And Methods: A retrospective study was conducted using 20 lateral cephalograms obtained using the NewTom GiANO HR cone-beam computed tomography (CBCT) system (Quantitative Radiology, Verona, Italy). Manual tracings were performed on acetate sheets, while digital analysis employed the AudaxCeph® software (Audax d.
Front Artif Intell
August 2025
Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
Precision livestock farming increasingly relies on non-invasive, high-fidelity systems capable of monitoring cattle with minimal disruption to behavior or welfare. Conventional identification methods, such as ear tags and wearable sensors, often compromise animal comfort and produce inconsistent data under real-world farm conditions. This study introduces Dairy DigiD, a deep learning-based biometric classification framework that categorizes dairy cattle into four physiologically defineda groups-young, mature milking, pregnant, and dry cows-using high-resolution facial images.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Spine Surgery, Zhongda Hospital Southeast University, 210009 Nanjing, Jiangsu, China.
Background: After spinal cord injury (SCI), pro-inflammatory microglia accumulate and impede axonal regeneration. We explored whether secreted protein acidic and rich in cysteine (Sparc) restrains microglial inflammation and fosters neurite outgrowth.
Methods: Mouse microglial BV2 cells were polarized to a pro-inflammatory phenotype with lipopolysaccharides (LPSs).