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http://dx.doi.org/10.1111/ijd.17776 | DOI Listing |
JDR Clin Trans Res
September 2025
Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Background: This systematic review aims to analyze the effectiveness of the combination of herbal medicine and corticosteroids in oral lichen planus (OLP) management. By providing an updated insight into the medicinal properties of this combined treatment approach, the review seeks to address the current gap in the understanding of its therapeutic potential for this chronic premalignant disorder.
Materials And Methods: PubMed, Web of Science, Scopus, Cochrane Library, CNKI, and WanFang databases were searched to identify randomized controlled trials comparing Chinese patent medicine (CPM) with corticosteroids and corticosteroids alone in treating OLP.
Pigment Cell Melanoma Res
September 2025
Department of Dermatology, CHU Nice, University Côte D'azur, Nice, France.
The term acquired dermal macular hyperpigmentation (ADMH) was introduced to unify Riehl's melanosis (RM), lichen planus pigmentosus (LPP), and related entities. These are cosmetically distressing pigmentary disorders that pose therapeutic challenges. To investigate the efficacy and safety of oral isotretinoin in treating ADMH, we conducted a muticenter retrospective study of patients with ADMH treated with oral isotretinoin between 2014 and 2024.
View Article and Find Full Text PDFDrug Deliv Transl Res
September 2025
Pharmaceutics and Drug Manufacturing Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, 11571, Egypt.
Oral lichen planus (OLP) is a chronic inflammatory disorder with limited topical treatment options and long-term corticosteroid dependency. This study investigates a novel atorvastatin-loaded hyalurosomal gel (ATV-Hyalugel) as a topical adjuvant to reduce systemic corticosteroid use in severe OLP. The objective of the study is to develop, optimize, characterize ATV-Hyalugel and evaluate its clinical efficacy in a randomized controlled clinical trial.
View Article and Find Full Text PDFJ Am Acad Dermatol
September 2025
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada; Donovan Hair Clinic, Whistler, BC, Canada. Electronic address:
J Inflamm Res
August 2025
Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Background: Oral lichen planus (OLP) is T cell-mediated inflammatory disease affecting the oral mucosa, and its molecular mechanism remains poorly understood.
Objective: This study aimed to screen for OLP-related hub genes and construct a network of competing endogenous RNAs (ceRNAs) to explore the crucial mechanisms involved in the disease.
Methods: Proteomic and transcriptomic sequencing were performed on oral mucosa collected from OLP patients and healthy participants, respectively.