Attenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1.

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 is a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomics, and thermal proteome profiling experiments, AP1G1, a pivotal protein involved in cellular endocytosis, was indiscriminately screened as a chaperone of SLC16A3.

Multifunctional Photoactive Janus Nanofibrous Membranes for Unidirectional Water Transport and Remediation of Airborne Pathogens and Pollutants.

Airborne pathogens and pollution control typically necessitate multiple membranes, each specializing in efficient aerosol filtration, moisture regulation, or antimicrobial protection. Integrating all these functions into a single membrane is highly advantageous but remains inherently challenging due to material incompatibility and inevitable performance trade-offs. Here, we present a photoactive Janus nanofibrous membrane for highly efficient air purification, engineered via sequential electrospinning.

To Evaluate the Effect of Pediatric Massage Combined with Comprehensive Management on Growth Parameters and Biochemical Indicators in Children with Short Stature.

Purpose: To investigated the effect of pediatric massage combined with comprehensive management on height improvement in children with short stature.

Patients And Methods: This retrospective analysis included medical records of 80 children diagnosed with short stature, who received treatment at Wuhu Hospital of Traditional Chinese Medicine between April 2022 and April 2023. According to the recorded treatment modalities, patients were divided into two groups: the control group received standard comprehensive management (including psychological health guidance, diet, sleep, exercise), while the massage group received additional pediatric syndrome-based massage therapy alongside comprehensive treatment.

Trimetallic Au-Ag-Cu Joint Doped Hydroxyapatite: Synergistic Photo-Fenton-Like Catalytic Performance Enhancement.

Photo-Fenton oxidation, as a promising wastewater treatment technology, suffers from double barriers: the sluggish Fenton catalytic rate of transition metal ions and inefficient visible light absorption, both of which severely constrain the performance enhancement of catalytic systems. Therefore, accelerating electron transfer processes and broadening optical absorption spectra have become critical scientific challenges for practical implementation. Herein, a composite catalyst system based on Au-Ag-Cu trimetallic species codoped on hydroxyapatite (HAp) was reported via an ion/ligand impregnation method.

Determination of Ethoxy Content in Ethylcellulose via Relative Quantitative H NMR Spectroscopy.

The research team established a quantitative H NMR method to determine the relative ethoxy content (EO%) in ethylcellulose using a CDCl/TFA-d solvent mixture. High-field NMR spectroscopy enabled direct measurement without the use of internal or external calibrants by integrating the methyl proton signals (δ 1.15 ppm) and the methylene/methine proton signals (δ 2.