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Accurate monitoring of blood glucose levels and the prediction of hyperglycemia are critical for the management of diabetes and the enhancement of medical efficiency. The primary challenge lies in uncovering the correlations among physiological information, nutritional intake, and other features, and addressing the issue of scale disparity among these features, in addition to considering the impact of individual variances on the model's accuracy. This paper introduces a universal, wearable device-assisted, multi-scale feature fusion model for real-time blood glucose monitoring and hyperglycemia prediction. It aims to more effectively capture the local correlations between diverse features and their inherent temporal relationships, overcoming the challenges of physiological data redundancy at large time scales and the incompleteness of nutritional intake data at smaller time scales. Furthermore, we have devised a personalized tuner strategy to enhance the model's accuracy and stability by continuously collecting personal data from users of the wearable devices to fine-tune the generic model, thereby accommodating individual differences and providing patients with more precise health management services. The model's performance, assessed using public datasets, indicates that the real-time monitoring error in terms of Mean Squared Error (MSE) is 0.22mmol/L, with a prediction accuracy for hyperglycemia occurrences of 96.75%. The implementation of the personalized tuner strategy yielded an average improvement rate of 1.96% on individual user datasets. This study on blood glucose monitoring and hyperglycemia prediction, facilitated by wearable devices, assists users in better managing their blood sugar levels and holds significant clinical application prospects.
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http://dx.doi.org/10.1016/j.medengphy.2025.104312 | DOI Listing |
J Anim Sci
September 2025
Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
It is helpful for diagnostic purposes to improve our current knowledge of gut development and serum biochemistry in young piglets. This study investigated serum biochemistry, and gut site-specific patterns of short-chain fatty acids (SCFA) and expression of genes related to barrier function, innate immune response, antioxidative status and sensing of fatty and bile acids in suckling and newly weaned piglets. The experiment consisted of two replicate batches with 10 litters each.
View Article and Find Full Text PDFJAMA Pediatr
September 2025
Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.
Importance: Youth living with type 1 diabetes (T1D) are increasingly choosing automated insulin delivery (AID) systems to manage their blood glucose. Few systematic reviews meta-analyzing results from randomized clinical trials (RCTs) are available to guide decision-making.
Objective: To study the association of prolonged AID system use in an outpatient setting with measures of glucose management and quality of life in youth with T1D.
Cell Mol Biol (Noisy-le-grand)
September 2025
M-DT1, Roquefort-les Pins, France.
To date, the closed-loop system represents the best commercialized management of type 1 diabetes. However, mealtimes still require carbohydrate estimation and are often associated with postprandial hyperglycemia which may contribute to poor metabolic control and long -term complications. A multicentre, prospective, non-interventional clinical trial was designed to determine the effectiveness of a novel algorithm to predict changes in blood glucose levels two hours after a usual meal.
View Article and Find Full Text PDFDiabetes Ther
September 2025
Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Trust, London, UK.
Introduction: This post hoc analysis of an A Toujeo Observational Study (ATOS) aims to evaluate the real-world effectiveness and safety of insulin glargine 300 U/ml (Gla-300) in high-risk subgroups of insulin-naïve people with type 2 diabetes (PwT2D) from multiple geographical regions (Asia, the Middle East, North Africa, Latin America, and Eastern Europe).
Methods: In these post hoc analyses of ATOS, a real-world, 12-month, prospective study included 4422 insulin-naïve adults (age ≥ 18 years) with type 2 diabetes (T2D) uncontrolled (HbA > 7% and ≤ 11%) on one or more oral antidiabetic drugs (OADs) who initiated Gla-300 treatment as per routine practice. Primary and secondary endpoints were studied according to renal impairment (RI) status (without or with) and age group (≥ 70 years).
Cell Mol Life Sci
September 2025
Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China.
Metabolic associated steatohepatitis (MASH) is a severe form of metabolic dysfunction-associated steatotic liver disease (MASLD) characterized by hepatocellular injury, inflammation, and fibrosis. Despite advances in understanding its pathophysiology, the molecular mechanisms driving MASH progression remain unclear. This study investigates the role of long non-coding RNA Linc01271 in MASLD/MASH pathogenesis, ant its involvement in the miR-149-3p/RAB35 axis and PI3K/AKT/mTOR signaling pathway.
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