Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cancer remains a significant global health challenge, necessitating the development of more effective therapeutic strategies. This work presents a novel glutathione (GSH)-responsive platform designed to enhance the delivery and efficacy of the anticancer drug mertansine (DM1) through the modulation of pendant groups in polycarbonate-drug conjugates. By systematically varying the hydrophobicity of the pendant groups, we investigated their effects on nanostructures, GSH sensitivity, colloidal stability, drug release profiles, and the anticancer efficacy of these polymeric nanoparticles, revealing that more hydrophobic pendant groups effectively reduce GSH accessibility for the nanoparticle cores, improve colloidal stability, and slow drug release rates. The results underscore the critical importance of polymer structures in optimizing drug delivery systems and offer valuable insights for future research on advanced nanomaterials with enhanced drug delivery for cancer therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939950 | PMC |
| http://dx.doi.org/10.1039/d5bm00163c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetism, Mössbauer Spectroscopy, and Proton Conductivity of Coordination Polymers Based on Phosphonate and Phosphinate Linkers.
J Phys Chem C Nanomater Interfaces
September 2025
Institute of Inorganic Chemistry of the Czech Academy of Sciences, Husinec-Řež 1001, 250 68 Řež, Czech Republic.
Coordination polymers (CPs) are versatile materials formed by metal ions and organic ligands, offering a broad range of structural and functional possibilities. Phosphonates and phosphinates are particularly attractive ligands for CPs due to their multiple binding sites, varied coordination geometries, and ability to form robust network structures. Phosphonates, considered harder ligands, form strong bonds with hard metals such as Fe, while phosphinates offer additional versatility due to the varied pendant groups on phosphorus.
View Article and Find Full Text PDFGreen Synthetic Amide-Modified Hyper-Cross-Linked Adsorption Resin for Efficiently Separating Chlorogenic Acid From Eucommia ulmoides Extracts.
J Sep Sci
September 2025
Guangzhou Institute of Energy Conversion, CAS Key Laboratory of Renewable Energy, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Eucommia ulmoides Oliver leaf is rich in chlorogenic acid, which has antioxidant, antiviral, and anti-inflammatory activities. In this work, a new and green strategy for functional hyper-crosslinked adsorption resin based on Friedel-Crafts reaction of pendant vinyl groups in divinylbenzene with anhydrous ethanol and acrylamide grafting polymerization was developed, and the obtained HCREt-AM resin had excellent performance on chlorogenic acid separation from Eucommia ulmoides Oliver leaf extract. Adsorption isotherm and kinetics study showed the adsorption process fitted by Langmuir adsorption isotherm and pseudo-second-order kinetic equation.
View Article and Find Full Text PDFA Bifunctional Cyclopropeneimine with a Tunable Hydrogen-Bond Donating Group and Its Application in the Enantioselective Synthesis of α,β-Diamino Phosphonates.
ACS Omega
September 2025
International Centre for Materials Science, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur- P.O., Bangalore 560064, India.
Lambert and co-workers have developed several chiral bases using a cyclopropeneimine as the basic moiety. Typically, these catalysts have a pendant hydroxyl group which acts as a hydrogen-bond donor and activates the electrophile. In catalysts with a hydrogen-bond donor, prior work from the Sigman group has shown that the acidity of the donor plays an important role in imparting selectivity.
View Article and Find Full Text PDFCapturing G protein-coupled receptors into native lipid-bilayer nanodiscs using new diisobutylene/maleic acid (DIBMA) copolymers.
Methods
September 2025
Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Physical Biology, Universitätsstr. 1, 40225 Düsseldorf, Germany; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany; Jülich Ce
Many membrane proteins, including G protein-coupled receptors (GPCRs), are susceptible to denaturation when extracted from their native membrane by detergents. Therefore, alternative methods have been developed, including amphiphilic copolymers that enable the direct extraction of functional membrane proteins along with their surrounding lipids. Among these amphiphilic copolymers, styrene/maleic acid (SMA) and diisobutylene/maleic acid (DIBMA) polymers have been extensively studied.
View Article and Find Full Text PDFSteering CO Electroreduction Pathway via Tuning Microenvironment of Cobalt Center in Molecular Catalysts.
ACS Nano
September 2025
Institut National de la Recherche Scientifique (INRS), Center Énergie Matériaux Télécommunications, Varennes, Québec J3X 1P7, Canada.
Owing to its chemical stability and molecular-level structural tunability, the molecular electrocatalyst cobalt phthalocyanine (CoPc) demonstrates significant potential for the electrochemical reduction of CO (CORR). However, the specific catalytic reaction process of CORR and the dynamic structural evolution mechanisms of CoPc remain a contentious subject. Elucidating the reaction pathways of CO electroreduction to CO and tracking structural evolution pose substantial challenges.
View Article and Find Full Text PDF