MksEF Accessory Proteins Inhibit MksB ATPase Activity and Modulate DNA Substrate Binding.

Chromosome organization and segregation are fundamental processes across all domains of life. In bacteria, the mechanisms governing nucleoid organization remain poorly understood. This study investigates the function of an alternative structural maintenance of chromosomes (SMC) complex, MksBEF, in .

Comparison Between Adenoid-Nasopharynx Ratio and Endoscopic Examination of Adenoid Hypertrophy: A Systematic Review and Meta-Analysis.

Otitis media is a major health issue that usually results from adenoid hypertrophy. Diagnosis is based on symptoms, such as mouth breathing, and imaging studies, including lateral neck radiography (LNR). The adenoid-nasopharyngeal ratio (ANR) is one of the most important and widely used criteria in LNR studies.

Correction: Esterase-induced release of a theranostic prodrug in lysosomes for improved therapeutic efficacy and lower systemic toxicity.

[This corrects the article DOI: 10.1039/D5SC03783B.].

A Bifunctional Cyclopropeneimine with a Tunable Hydrogen-Bond Donating Group and Its Application in the Enantioselective Synthesis of α,β-Diamino Phosphonates.

Lambert and co-workers have developed several chiral bases using a cyclopropeneimine as the basic moiety. Typically, these catalysts have a pendant hydroxyl group which acts as a hydrogen-bond donor and activates the electrophile. In catalysts with a hydrogen-bond donor, prior work from the Sigman group has shown that the acidity of the donor plays an important role in imparting selectivity.

Metabolomics in Endocrinology: The Way Forward.

Metabolomics is a type of laboratory science used to understand the cellular and metabolic defects in any disease process. It comprehensively identifies endogenous and exogenous low-molecular-weight (<1 kDa) molecules or metabolites in a high-throughput manner. Mass spectrometry-based methods are used for metabolomics which can be targeted and non-targeted.

Exploring the Interthalamic Adhesion: A Comprehensive Review of Its Morphology, Neuroconnectivity and History of Research.

The interthalamic adhesion, or massa intermedia, is a midline bridge of neural tissue connecting the thalami across the third ventricle and usually containing the nucleus reuniens. It is important radiologically and neurosurgically: accessing the third ventricle or structures through the third ventricle, endoscopic surgery at third ventricle. We aim to consolidate current knowledge on the interthalamic adhesion, focusing on its morphology, nomenclature, development, histology, connections and anatomical variations to clarify longstanding inconsistencies.

Multifunctional polyamidoxime-co-polyethyleneimine tailored cellulose derived from sustainable biomass for effective removal of acidic dye pollutants from wastewater.

Multifunctional polymers derived from waste biomass are under intense global investigation for wastewater remediation owing to their environmental advantages. Therefore, this study reports the synthesis of a novel polyamidoxime-co-polyethyleneimine multifunctional cellulose, which was used as an adsorbent for the removal of acidic dye pollutants. Morphological, structural, and surface studies were performed using several techniques.

Solvent-dependent reactivity of azo-BF switches.

Azo-BF complexes are visible and near-infrared (NIR) light-activated photoswitches showcasing versatility in applications ranging from energy storage to three-dimensional displays. While highly appealing as molecular switches, factors that affect their photophysical properties and solution-state reactivity still need to be teased out. In this paper, we present the synthesis and characterization of two azo-BF analogues (1 and 2), each modified with structurally distinct dimethylamine-substituted naphthalene moieties.

Outpatient Endocrine Protocol and Testing Coincides with Reduced Length of Postpituitary Surgery Admission.

Objective: The study objective was to compare the length of stay (LOS) and the proportion of one-night admissions before and after the implementation of an endocrine monitoring protocol following endoscopic transsphenoidal surgery (ETSS) for pituitary adenoma.

Methods: Patients who underwent transsphenoidal pituitary adenoma resection between July 1, 2018, and September 9, 2022, were identified, and divided into two cohorts before and after the implementation of the monitoring protocol. The overall LOS and number of nights of admission were recorded.

2D Cadmium Chalcogenide Nanoplatelets: Recent Progress and Opportunities.

Emerging research on 2D cadmium chalcogenide nanoplatelets (NPLs) has garnered significant interest due to their large absorption cross-section, narrow emission band, fast photoluminescence decay, high optical gain, and significant giant oscillator strength transitions, which render them highly suitable for optoelectronic devices. This Perspective highlights their ultrafast decay dynamics and their applications in photodetectors, nonlinear properties, electrocatalysis, and photocatalysis. A deeper understanding of excited-state charge carrier dynamics is crucial for optoelectronic applications, particularly in photodetectors, nonlinear properties, and photocatalytic systems, where charge separation and transfer are essential.

Redox-Assisted Controlled Radical Polymerization of Acrylates by Strategically Designed Ru-Fe Heterobimetallic Conjugate.

Employing heterobimetallic complexes (HBCs) offers an exciting and powerful strategy for various catalytic applications. Here, we present an unorthodox synthetic route to synthesize a novel Ru-Fe heterobimetallic complex by implementing the strategy of "metalation with functionalization." This complex utilizes a redox-assisted concerted strategy to facilitate the controlled radical polymerization (CRP) of acrylate monomers with significantly low catalyst loading.

SALSA: a novel flow cytometry assay to detect ascorbate at the single-cell level.

Ascorbate (AA) is an essential antioxidant and enzymatic cofactor with emerging roles in epigenetic regulation, redox biology, and immune function. However, single-cell quantification of intracellular AA has remained technically challenging. Here, we present SALSA (Single-cell Ascorbate Level Sensing Assay), a novel flow cytometry-based method that enables sensitive, specific detection of intracellular AA at the single-cell level.

Neonatal evaluation by extended (12 area) vs. traditional (6 area) lung ultrasound scoring (NEXT-LUS): a prospective observational study.

Background: Lung ultrasound (LUS) offers a safe, repeatable, radiation-free tool in management of respiratory distress in neonates. Despite wide use, limited data exists on optimal scoring approaches.

Methodology: A prospective observational study was conducted over 6 months in a tertiary neonatal intensive care unit (NICU) enrolling neonates with respiratory distress within 2 h of admission after consent.

Arylthianthrenium Salts Enabled Palladium-Catalyzed Regioselective Arylation: Access to Value-Added 7-Azaindoles.

A step-economic and efficient palladium-catalyzed protocol for regioselective C-2 arylation of 7-azaindoles with arylthianthrenium salts has been developed under base- and ligand-free conditions. The reaction proceeds smoothly with broad substrate scope, requires low catalyst loading, exhibits excellent functional group tolerance, and provides C-2 arylated products in moderate to excellent yields. Moreover, given the ready availability of arylthianthrenium salts from simple arenes, this strategy offers a valuable platform for the late-stage functionalization of structurally complex and bioactive molecules.

Rhodamine and functionalised azobenzene condensed fluorescent novel receptor for the selective and sensitive detection of Hg: a combined experimental and theoretical study.

Rhodamine dye has a high absorption coefficient, fluorescence quantum yield, photostability, and extended wavelengths that make it a promising fluorescent probe. A rhodamine and functionalised azobenzene condensed novel chemosensor L has been reported for the first time to detect Hg in aqueous ethanol optically in this investigation. Chemosensor L's fluorescence activation in response to Hg is due to the suppression of PET and CHEF processes and the change from spirolactam to ring-opened amide.

-annulated unsymmetrical perylene ester imide exhibiting room-temperature columnar hexagonal mesophases.

Incorporating heteroatoms into π-conjugated aromatic cores enables the formation of robust self-assembled architectures by leveraging enhanced intermolecular interactions, including dipole-dipole, van der Waals, and σ-hole mediated non-covalent interactions. These improved self-assemblies are key for achieving superior performance in organic semiconductors. Herein, we present the rational design and synthesis of a selenium-annulated unsymmetrical perylene diester imide (PEI-SeST), wherein a swallow-tail moiety at the imide position, in concert with decyl substituents at the ester functionalities, stabilizes an enantiotropic columnar hexagonal liquid crystalline phase at ambient temperature, which is in contrast to the perylene ester imide derivative without a heteroatom.

Poly(-acryloyl-L-phenylalanine) nanoparticles for potential treatment of inflammation in selective organs.

Systemic inflammation can lead to multi-organ failure. The existing anti-inflammatory agents show adverse side effects, and the present situation demands new drugs with high therapeutic efficiency. Polymeric nanoparticles based on amino acids could be one of the best alternative solutions due to their cytocompatibility and immune responses.

Palladium-Catalyzed Decarboxylative Cross-Coupling of 2,4-Dienoic Acids and Aryl Halides: Access to Fluorescence Active ()-1,4-Diarylbutadienes.

A range of (,)-1,4-diarylbutadienes has been efficiently achieved through a Pd-catalyzed decarboxylative cross-coupling of various 2,4-dienoic acids with diverse (hetero)aryl halides, such as bromides, chlorides, and iodides. This protocol successfully produces the corresponding 1,4-diarylbutadiene cross-coupled products in high yields across a large range of substrates (68 examples), demonstrating compatibility with various sensitive functional groups, including heterocycles. A catalytic amount of silver salt was used as a cocatalyst in this approach, replacing the stoichiometric amounts utilized in earlier reports.

An explainable ML model for binary LJ fluids.

Lennard-Jones (LJ) fluids serve as an important theoretical framework for understanding molecular interactions. Binary LJ fluids, where two distinct species of particles interact based on the LJ potential, exhibit rich phase behavior and provide valuable insights into complex fluid mixtures. Here we report the construction and utility of a machine learning (ML) model for binary LJ fluids, focusing on their effectiveness in predicting radial distribution functions (RDFs) across a range of conditions.

Exploring impact of cold atmospheric plasma directed self-assembly of glycated bovine serum albumin.

Bovine Serum Albumin (BSA) is a globular, water-soluble protein widely used as a model system due to its stability, binding capacity, and structural similarity to human serum albumin (HSA). Cold atmospheric plasma (CAP) has emerged as a versatile tool for biomolecule modification, sterilization, food preservation, and wound healing. This study explores the effects of CAP on glycated BSA, focusing on structural and self-assembly processes.

Quinoxaline Based Three Channel Fluorescent-colorimetric Chemosensor for Selective and Sensitive Detection of Ag Ions: Biological and Environmental Applications.

Herein we describe a quinoxaline mono Schiff base, synthesised from benzil and o-phenylene diamine that may be used as a fluorescent-colourimetric chemosensor to detect Ag ions in organic media with high selectivity and sensitivity over other competitive ions. The sensing processes were operated by visual change, absorption, and emission measurements, and the binding sites were confirmed by FTIR and single-crystal structure of the Ag(I)- complex. From Job-plot analysis, ESI-mass spectra and XRD studies 1:2 binding stoichiometry between host-guest was observed.

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis.

Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD) simulations to evaluate the potential of repurposing terfenadine and domperidone for inhibition of apoptotic gene associations in CRC. Network pharmacology analysis identified 4 principal targets-SLC6A4 (5I6X), DRD2 (7DFP), HTR2A (6WGT), and EGFR (6LUD)-involved in the apoptotic regulatory network.

A Catalytic Perspective on Erythromycin Hydrolysis by Erythromycin Esterase C: Combined CpHMD and QM/MM Metadynamics Study.

Macrolide esterases, which are preponderant drug-inactivating enzymes present inside drug-resistant bacteria, pose a significant threat to the realm of macrolide antibiotics. They dissect the antibiotic's macrolactone ring structure by hydrolyzing the ester moiety, consequently diminishing the antimicrobial efficacy in treating bacterial infections. Motivated by the recently resolved crystallographic structure of an important member of the macrolide esterase - 'Erythromycin Esterase C (EreC)' - we have delved into the catalytic itineraries of the erythromycin hydrolysis utilizing QM/MM methods.