Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328089 | PMC |
| http://dx.doi.org/10.1002/cac2.70022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis.
Carcinogenesis
September 2025
Department of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611-3010, USA.
Esophageal cancer is a major cause of cancer-related death, often preceded with chronic inflammation and injuries. The NFκB/IKKβ pathway plays a central role in inflammation, yet its role in early esophageal carcinogenesis remains unclear. This study investigated the role of epithelial IKKβ in early esophageal carcinogenesis.
View Article and Find Full Text PDFTargeted deletion of Cyp24a1 in the intestine reduces mucosal injury and preserves epithelial proliferation after 5-fluorouracil treatment.
J Steroid Biochem Mol Biol
September 2025
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia. Electronic address:
Vitamin D has been proposed to attenuate chemotherapy-induced gastrointestinal mucositis (GM). In the intestine, local catabolism of active vitamin D [1,25-dihydroxyvitamin D₃] is mediated by the enzyme Cyp24a1. This study assessed whether deletion of Cyp24a1 specifically in intestinal epithelial cells can protect against 5-fluorouracil (5-FU)-induced intestinal injury and microbiome disruption in mice.
View Article and Find Full Text PDFThe complement component C3, factor B (FB) and factor D (FD) belong to the alternative complement pathway and have been identified in urine samples from nephrotic mice. However, it is not yet known whether these factors are involved in mediating sodium retention in nephrotic syndrome (NS). Here we used a genetic mouse model of NS based on an inducible podocin deletion ( ).
View Article and Find Full Text PDFMicrobiota-dependent formylated peptide receptor (Fpr1/2) signaling regulates enteric nervous system development and gastrointestinal motility in mice.
Cell Mol Gastroenterol Hepatol
September 2025
Department of Pathology & Laboratory Medicine, Emory University, Atlanta, USA. Electronic address:
Background & Aims: Formylated peptide receptors 1 and 2 (Fpr1/2 or FPRs) are G-protein-coupled pattern recognition receptors that bind bacterial formylated peptides. The role of FPRs in enteric nervous system (ENS) development and gastrointestinal (GI) motility is unknown.
Methods: We generated mice with germline, epithelial-, and neural crest-specific deletion of the Fpr1/2 locus and assessed ENS structure and GI motility.
Fatty acid 2-hydroxylase facilitates rotavirus uncoating and endosomal escape.
Proc Natl Acad Sci U S A
September 2025
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped double-stranded RNA viruses and the leading cause of severe dehydrating diarrhea in infants and young children. We identified fatty acid 2-hydroxylase (encoded by ) in the fatty acid 2-hydroxylation pathway as a proviral gene that supports RV infection.
View Article and Find Full Text PDF