98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.2215/CJN.0000000714 | DOI Listing |
Clin Res Cardiol
September 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, Center for Translational and Experimental Cardiology (CTEC), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.
Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.
Clin Kidney J
September 2025
Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Genome editing technologies, particularly clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, have transformed biomedical research by enabling precise genetic modifications. Due to its efficiency, cost-effectiveness and versatility, CRISPR has been widely applied across various stages of research, from fundamental biological investigations in preclinical models to potential therapeutic interventions. In nephrology, CRISPR represents a groundbreaking tool for elucidating the molecular mechanisms underlying kidney diseases and developing innovative therapeutic approaches.
View Article and Find Full Text PDFClin Interv Aging
September 2025
Department of Ultrasound Medicine, Clinical Medical College, First Affiliated Hospital of Chengdu Medical College, Chengdu, People's Republic of China.
The incidence of chronic kidney disease (CKD) has been consistently rising in recent years. This trend is particularly concerning in the aging population, where the prevalence of CKD and cardiovascular disease is disproportionately high. Among CKD patients, cardiovascular disease stands as the primary prognostic risk factor and leading cause of mortality.
View Article and Find Full Text PDFClin Pharmacol
September 2025
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.
Red yeast rice (RYR) is an Asian indigenous medicine that ferments grains using the Monascus fungi, specifically . Monacolins, pigments, phenols, sterols, and benzopyrans, such as the mycotoxin citrinin, were proven to be present in RYR, contributing to its numerous effects. This study aims to provide a thorough overview of the in vitro and in vivo pharmacological activities of red yeast rice, its studies in humans, and a summary of recent case reports.
View Article and Find Full Text PDFThe relationship between gut microbiota, diet, and cardiovascular-kidney-metabolic (CKM) health has attracted attention. However, the relationship between the dietary index for gut microbiota (DI-GM) and CKM syndrome has not yet been studied. Patients diagnosed with CKM syndrome from the NHANES 2007-2018 data were included.
View Article and Find Full Text PDF