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The detection of organic pollutants at ultra-low concentrations is crucial for environmental monitoring, yet existing surface-enhanced Raman scattering (SERS) platforms often suffer from limited sensitivity, poor stability, and inconsistent signal reproducibility. To address these challenges, this study presents a high-performance SERS platform based on in situ gold (Au) nanoparticle-engineered TiCT MXenes. This novel approach enhances signal amplification and ensures long-term stability for pollutant detection. The platform achieves an exceptional limit of detection (LOD) of 10 M with an enhancement factor of 10 for Methylene Blue (MB), demonstrating its superior sensitivity. Additionally, signal repeatability has been validated by calculating the relative standard deviation (RSD), and the SERS substrate retains 83% of its signal intensity after 5 months of storage, confirming its durability. Furthermore, the platform effectively detects polybrominated diphenyl ether (BDE-47), a persistent organic pollutant, at concentrations below the regulatory threshold of 10 M. These results highlight the potential of the proposed SERS platform for reliable and long-term environmental monitoring of hazardous substances.
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http://dx.doi.org/10.1007/s00604-025-07067-3 | DOI Listing |
J Phys Chem Lett
September 2025
Shandong Provincial Engineering and Technical Center of Light Manipulation, School of Physics and Electronics, Shandong Normal University, Jinan 250014, P.R. China.
Heterostructures have emerged as promising contenders for surface-enhanced Raman scattering (SERS) applications. Nevertheless, the construction of a composite SERS substrate with well-matched energy levels persists as a challenge, primarily due to the restricted selection of SERS-active materials. In this study, we successfully synthesized a Ag nanoparticles (NPs)/ZnO nanorods (NRs)/GaN heterojunction featuring type II staggered energy bands, which provides an outstanding platform for efficient SERS detection.
View Article and Find Full Text PDFSmall
September 2025
Jožef Stefan Institute, Jamova cesta 39, Ljubljana, SI-1000, Slovenia.
The demand for rapid, field-deployable detection of hazardous substances has intensified the search for plasmonic sensors with both high sensitivity and fabrication simplicity. Conventional approaches to plasmonic substrates, however, often rely on lithographic precision or complex chemistries limiting scalability and reproducibility. Here, a facile, one-step synthesis of vertically aligned 2D nanosheets composed of intergrown CuO/CuO crystallites is presented, fabricated via oxygen plasma discharge on copper substrates.
View Article and Find Full Text PDFMethods
September 2025
Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang 150081, PR China. Electronic address:
Single-cell surface-enhanced Raman scattering (SERS) has emerged as a powerful tool for precision medicine owing to its label-free detection, ultrasensitivity, and unique molecular fingerprinting. Unlike conventional bulk analysis, it enables detailed characterization of cellular heterogeneity, with particular promise in circulating tumor cell (CTC) identification, tumor microenvironment (TME) metabolic profiling, subcellular imaging, and drug sensitivity assessment. Coupled with microfluidic droplet systems, SERS supports high-throughput single-cell analysis and multiparametric screening, while integration with complementary modalities such as fluorescence microscopy and mass spectrometry enhances temporal and spatial resolution for monitoring live cells.
View Article and Find Full Text PDFCell Rep Med
August 2025
Center for Biomedical-photonics and Molecular Imaging, Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; Engineering Research Center of Mole
Rapid identification and accurate diagnosis are critical for individuals with acute leukemia (AL). Here, we propose a combined deep learning and surface-enhanced Raman scattering (DL-SERS) classification strategy to achieve rapid and sensitive identification of AL with various subtypes and genetic abnormalities. More than 390 of cerebrospinal fluid (CSF) samples are collected as targets, encompassing healthy control, AL patients, and individuals with other diseases.
View Article and Find Full Text PDFVirology
September 2025
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China. Electronic address:
Colloidal gold technology has revolutionized viral diagnostics through its rapid, cost-effective, and user-friendly applications, particularly in point-of-care testing (POCT). This review synthesizes recent advancements, focusing on its role in detecting respiratory viruses, hepatitis viruses, and emerging pathogens. The technology leverages the unique optical and physicochemical properties of gold nanoparticles (AuNPs), including localized surface plasmon resonance (LSPR) and high surface-to-volume ratios, to achieve rapid antigen-antibody recognition with visual readouts within 15 min.
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