Effect of Kisspeptin Fortification in Freezing Media on Post-Thaw Quality and Fertility of Buffalo Bull Semen.

The present study was undertaken to assess the effect of kisspeptin supplementation (0.0, 5.0, 10.

Interfacial engineering of CuSe/FeSe heterojunctions for water splitting: a pathway to high-performance hydrogen and oxygen evolution reactions.

The efficiency of green hydrogen production water electrolysis is critically constrained by high energy barriers, particularly during the oxygen evolution reaction (OER). In this study, CuSe/FeSe heterojunctions are introduced as cost-effective and highly active bifunctional electrocatalysts for overall water splitting. Leveraging the abundant and tunable properties of Cu- and Fe-based chalcogenides, this work demonstrates how charge redistribution and interfacial electronic coupling in the heterostructure significantly enhance catalytic activity.

Electrocatalytic Performance of MX MXenes for Hydrogen Evolution Reaction.

MX MXenes, a subclass of 2D transition metal carbides, have attracted attention as the thickest 2D material synthesized. Early studies show their promising electrocatalytic activity but overlooked how metal composition and interlayer spacing affect hydrogen evolution reaction (HER). To address this gap, three MX MXenes, MoVC, (TiTa)C, and (TiNb)C, are systematically studied and their interlayer spacing and composition modulated through ion exchange with tetramethyl ammonium (TMA vs.

Au nanoparticle-engineered TiCT MXenes as a high-performance SERS platform for detection of organic pollutants.

The detection of organic pollutants at ultra-low concentrations is crucial for environmental monitoring, yet existing surface-enhanced Raman scattering (SERS) platforms often suffer from limited sensitivity, poor stability, and inconsistent signal reproducibility. To address these challenges, this study presents a high-performance SERS platform based on in situ gold (Au) nanoparticle-engineered TiCT MXenes. This novel approach enhances signal amplification and ensures long-term stability for pollutant detection.

Enhancing NiS performance: Na-doping for advanced photocatalytic and electrocatalytic applications.

Alkali metal doping is a new and promising approach to enhance the photo/electrocatalytic activity of NiS-based catalyst systems. This work investigates the impact of sodium on the structural, electronic, and catalytic properties of NiS. Comprehensive characterization techniques demonstrate that Na-doping causes significant changes in the NiS lattice and surface chemistry translating into a larger bandgap than NiS.

Role of MMP-9 and NF-κB in Diabetic Retinopathy: Progression and Potential Role of Bioflavonoids in the Mitigation of Diabetic Retinopathy.

"Diabetes mellitus" is a chronic metabolic disorder manifested by elevated blood glucose levels, primarily due to insufficient insulin production or resistance to insulin. Long-term diabetes results in persistent complications like retinopathy, cardiomyopathy, nephropathy, and neuropathy, causing significant health risks. The most alarming microvascular consequence allied with diabetes is "diabetic retinopathy," distinguished by the proliferation of anomalous blood vessels in the eye, mainly in the retina, resulting in visual impairment, diabetic macular edema, and retinal detachment if left untreated.

The Impact of Gender Diversity on Excellence in Pathology Research and Education.

In this editorial, we inspect the critical role of gender diversity within the domain of pathology and its consequential impact on research innovation and clinical outcomes. The editorial commences with a historical overview of gender disparities in pathology, acknowledging advancements toward gender parity while highlighting persistent impediments to full inclusivity. The discourse emphasizes the intrinsic value of integrating diverse gender perspectives in research, illustrating how such inclusivity catalyzes innovation, mitigates research biases, and elevates the standard of patient care through a more comprehensive understanding of the field of pathology.

Pathology in the Age of Artificial Intelligence (AI): Redefining Roles and Responsibilities for Tomorrow's Practitioners.

The evolution of pathology from its rudimentary beginnings around 1700 BC to the present day has been marked by profound advancement in understanding and diagnosing diseases. This journey, from the earliest dissections to the modern era of histochemical analysis, sets the stage for the next transformative leap to the integration of artificial intelligence (AI) in pathology. Recent research highlights AI's significant potential to revolutionize healthcare within the next decade, with a particular impact on diagnostic processes.

Cyto and Genoprotective Potential of Tannic Acid Against Cadmium and Nickel Co-exposure Induced Hepato-Renal Toxicity in BALB/c Mice.

Tannic acid (TA) is a metal chelating polyphenol that plays a crucial role in metal detoxification, but its modulatory role in co-exposure of these heavy metals' exposure needs to be explored. Cadmium (Cd) and nickel (Ni) are inorganic hazardous chemicals in the environment. Humans are prone to be exposed to the co-exposure of Cd and Ni, but the toxicological interactions of these metals are poorly defined.

A Case Report of Systemic Allergic Reaction to the Dual Glucose-Dependent Insulinotropic Polypeptide/Glucagon-Like Peptide-1 Receptor Agonist Tirzepatide.

This report examines a case of systemic hypersensitivity to tirzepatide in a patient with type 2 diabetes. Tirzepatide (Mounjaro®), a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor, has recently gained FDA approval. Additionally, a literature review was conducted to summarize recent research on tirzepatide's effectiveness and safety.

Unleashing the power of solar light: WO nanorods decorated onto BiVO dendrites for tetracycline detoxification and water splitting.

The coupling of different oxide materials in a nanohybrid enables the customization of their optical and charge transport properties, leading to improved interfacial charge segregation and migration. In this study, BiVO/WO (BVW), a sunlight-driven photocatalyst with distinct mole ratios was synthesized via a facile hydrothermal approach. The resultant catalyst exhibits a nanorods shape morphology decorated onto dendrite-like matrix and is studied for photocatalytic elimination of tetracycline (TC) and photoelectrocatalytic (PEC) H production.

Severe COVID-19 Myocarditis in a Young Unvaccinated Patient.

Coronavirus disease 2019 (COVID-19) myocarditis is a rare but serious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been associated with high-case fatality. For a very long time, since the beginning of the pandemic, there were no definitive guidelines to diagnose and manage this condition, probably secondary to the gaps in understanding the exact pathophysiology of the disease. We present the case of a young, unvaccinated female, with no comorbidities, who had an aggressively progressive COVID-19 myocarditis that was fatal.

Persistent Hypokalemia in a Patient With Ogilvie's Syndrome.

Ogilvie's syndrome, also known as acute colonic pseudo-obstruction (ACPO), is a rare disease characterized by acute dilatation of the colon in the absence of anatomic intestinal obstruction. It is of clinical importance because of its preponderance in elderly males in the seventh decade of life who may present with constipation or diarrhea. We present an 80-year-old male who presented with diarrhea, with laboratory investigations showing hypokalemia and a CT abdomen revealing colonic distension.

Plasmonic Copper-activated ZnO Microarrays for Efficient Photoelectrocatalytic Applications.

In the present work, green synthesized plasmonic copper nanostructures derived from carbon quantum dots (PCQDs) activated ZnO microarrays (MAs) based catalyst system is developed and studied for photocatalytic activity and photoelectrocatalytic water splitting. CQDs are synthesized from pharmaceutical waste and used as a reducing agent to synthesize PCQDs of an average size of 10±2 nm. PCQDs decorated ZnO (PCQDs/ZnO) MAs exhibited enhanced photocurrent density of ∼7.

Heavy metals in vegetables: a review of status, human health concerns, and management options.

For sustainable global growth, food security is a prime concern issue, both quantitatively and qualitatively. Adverse effects on crop quality from contaminants like heavy metals have affected food security and human health. Vegetables comprise the essential and nutritious part of the human diet as they contain a lot of health-promoting minerals and vitamins.

Environmental and health impacts of contaminants of emerging concerns: Recent treatment challenges and approaches.

In the past few decades, new contaminants of emerging concern (CECs) in the air, water, and soil have gained significant attention due to their adverse impact on human health and the environment. The sources of CECs have been identified in different forms from domestic and industrial activities such as personal care products and pharmaceuticals. It has been established that aqueous medium plays a major role in the dissemination of various contaminants, like drinking water, reservoirs, lakes, rivers and waste with water medium.

A Comprehensive Review on Water Quality Monitoring Devices: Materials Advances, Current Status, and Future Perspective.

Water quality monitoring has become more critical in recent years to ensure the availability of clean and safe water from natural aquifers and to understand the evolution of water contaminants across time and space. The conventional water monitoring techniques comprise of sample collection, preservation, preparation, tailed by laboratory testing and analysis with cumbersome wet chemical routes and expensive instrumentation. Despite the high accuracy of these methods, the high testing costs, laborious procedures, and maintenance associated with them don't make them lucrative for end end-users and field testing.

Targeting of Uropathogenic Escherichia coli papG gene using CRISPR-dot nanocomplex reduced virulence of UPEC.

Urinary tract infections (UTI) are the most common infectious diseases in the world. It is becoming increasingly tough to treat because of emergence of antibiotic resistance. So, there is an exigency to develop novel anti-virulence therapeutics to combat multi-drug resistance pathogenic strains.

Alleviation of heat stress by Chlorophytum borivilianum: impact on stress markers, antioxidant, and immune status in crossbred cows.

Eighteen crossbred Karan Fries (KF) cows in mid-lactation (av. 130 days) were selected from the livestock herd of the institute. The treatment for the experimental cows was as follows: no supplement (control), a low dose of Chlorophytum borivilianum (CB) at a dose rate of 40 mg/kg BW/day (T1, n = 6), and a high dose of CB at a dose rate of 80 mg/kg BW/day (T2, n = 6) for a period of 90 days in hot-humid season.

Effect of Chlorophytum borivilianum supplementation on milk production, composition and fatty acid profile in crossbred cows during hot-humid season.

The present investigation was carried out to test the efficacy of Chlorophytum borivilianum (CB) supplementation on milk production, composition, and fatty acid profile in crossbred (KF) cows. Eighteen crossbred cows were selected randomly from the institute herd and divided as control (n = 6), treatment 1 (T1, n = 6) and treatment 2 (T2, n = 6) based on body weight (av. 410.

Nanostructures derived from expired drugs and their applications toward sensing, security ink, and bactericidal material.

In this research, a facile and economical route is introduced for the transformation of pharmaceutical waste (i.e., expired medicines) into value-added fluorescent carbon quantum dots (pharmaceutically derived CQDs abbreviated as 'P-CQDs').