Synthesis, characterization and bio-evaluation of novel series of pyrazoline derivatives as potential antifungal agents.

In this study, a series of novel α, β-unsaturated carbonyl compounds (3a-j) and their pyrazoline derivatives (4a-e and 5a-b) were designed and successfully synthesized. All synthesized compounds were characterized using various spectroscopic techniques, including H NMR, C NMR, and mass spectrometry. The biological activity of these compounds was evaluated against five bacterial strains (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Acinetobacter baumannii) and three fungal strains (Candida tropicalis, Candida parapsilosis, and Candida albicans).

Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules: Traditional to Modern Approach.

Computer-Aided Drug Design (CADD) entails designing molecules that could potentially interact with a specific biomolecular target and promising their potential binding. The stereo- arrangement and stereo-selectivity of small molecules (SMs)--based chemotherapeutic agents significantly influence their therapeutic potential and enhance their therapeutic advantages. CADD has been a well-established field for decades, but recent years have observed a significant shift toward acceptance of computational approaches in both academia and the pharmaceutical industry.

Thoracic Complications in Supracostal Percutaneous Nephrolithotomy.

Background: Due to the risk of pleural injury leading to thoracic complications, many urologist still hesitate to perform supracostal puncture during percutaneous nephrolithotomy. Our aim of this study was to evaluate the thoracic complications in supracostal access percutaneous nephrolithotomy.

Methods: This is a retrospective analysis of 101 patients who were treated with supracostal access percutaneous nephrolithotomy at our institute from September 2013 and December 2019.

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers.

In recent decades, "environmental xenobiotic-mediated endocrine disruption", especially by xeno-estrogens, has gained a lot of interest from toxicologists and environmental researchers. These estrogen-mimicking chemicals are known to cause various human disorders. Pesticides are the most heavily used harmful xenobiotic chemicals around the world.

Heavy metals in vegetables: a review of status, human health concerns, and management options.

For sustainable global growth, food security is a prime concern issue, both quantitatively and qualitatively. Adverse effects on crop quality from contaminants like heavy metals have affected food security and human health. Vegetables comprise the essential and nutritious part of the human diet as they contain a lot of health-promoting minerals and vitamins.

Plasminogen activator inhibitor-1 promoter sequence variations in idiopathic osteonecrosis of head of femur.

Background & Objectives: Primary or idiopathic osteonecrosis of femur head (ONFH) is the second most commonly observed cause among Indian patients suffering from ischemic ONFH. Although a number of genetic polymorphisms have been associated with idiopathic ONFH pathogenesis in Korean and Chinese populations, there are no studies in the Indian population. This is an exploratory study designed to implicate in promoter sequence polymorphisms of a critical fibrinolytic system regulator, plasminogen activator inhibitor-1 (PAI-1) gene, in cases of idiopathic osteonecrosis.

Sentiment Analysis of Statements on Social Media and Electronic Media Using Machine and Deep Learning Classifiers.

When it comes to our everyday life, emotions have a critical role to play. It goes without saying that it is critical in the context of mobile-computer interaction. In social and mobile communication, it is vital to understand the influence of emotions on the way people interact with one another and with the material they access.

Glaucoma Detection Using Image Processing and Supervised Learning for Classification.

A difficult challenge in the realm of biomedical engineering is the detection of physiological changes occurring inside the human body, which is a difficult undertaking. At the moment, these irregularities are graded manually, which is very difficult, time-consuming, and tiresome due to the many complexities associated with the methods involved in their identification. In order to identify illnesses at an early stage, the use of computer-assisted diagnostics has acquired increased attention as a result of the requirement of a disease detection system.

An Unusual Presentation of Squamous Cell Carcinoma of Kidney.

Primary squamous cell carcinoma of the renal pelvis is an extremely rare entity representing only 0.5% to 0.8% of all urothelial malignancies.

COVID pandemic analysis using Auto- Regression-Based moving average method.

COVID (Corona Virus) 2019 proved to be a pandemic worldwide, with more than 30 lakhs of life's in danger and more than 2 lakh people dead as of 01 May 2020. The disease is spreading across the world in various phases, with assumptions of having an impact based on the weather conditions, where the true reason is not yet confirmed. However, several precautionary measures such as maintaining social distancing, covering mouth and hands using masks and gloves, avoiding huge public gatherings to attend conferences, meetings, worship places, etc proved to put a pause on the spread of this air-borne contagious disease.

A novel single myocapsular sleeve (SMS) repair technique to reduce dislocation in posterior approach to the hip: A clinico-radiographic study.

Background: To assess a new modification of posterior approach to the hip and its effect on stability and functional outcome in total hip arthroplasty.

Material & Methods: A comparative retrospective study was done to assess the functional outcome and rate of dislocation among 233 hips (Group A) operated by conventional posterior approach and 567 hips (Group B) by our novel modified posterior approach. In this technique, 2-3 stay sutures are applied in external rotators, then a single conjoint-myocapsular sleeve is raised linearly over the capsule with adherent fibers of gluteus minimus to piriformis tendon, short rotators and part of quadratus for exposure of femoral head.

Comparative study of single lateral locked plating versus double plating in type C bicondylar tibial plateau fractures.

Background: Bicondylar tibial plateau fractures are complex injuries and treatment is challenging. Ideal method is still controversial with risk of unsatisfactory results if not treated properly. Many different techniques of internal and external fixation are used.

Association of CYP1A1, CYP1B1 and CYP17 gene polymorphisms and organochlorine pesticides with benign prostatic hyperplasia.

It is well established that steroidal hormones (testosterone and estrogen) increase benign prostatic hyperplasia (BPH) risk. Cytochrome P450 (CYP) enzymes especially CYP1A1, CYP1B1 and CYP17 metabolize these hormones. Apart from that, several endocrine disrupting organochlorine pesticides (OCPs) are reported to mimic the activity of these steroidal hormones.

Heavy metal levels in adolescent and maternal blood: association with risk of hypospadias.

Background. Hypospadias is a part of testicular digenesis syndrome (TDS) which includes infertility, cryptorchidism, and spermatogenesis. Heavy metals act as endocrine disrupting compounds.

Role of nonoperative treatment in managing degenerative tears of the medial meniscus posterior root.

Background: Tears of the medial meniscus posterior root can lead to progressive arthritis, and its management has no consensus. The aim of our study was to evaluate the effect of supervised exercise therapy on patients with medial meniscus posterior root tears.

Materials And Methods: Between January 2005 and May 2007, 37 patients with this tear verified by magnetic resonance imaging (MRI) and osteoarthritis grade 1-2 by radiographic examination were treated by a short course of analgesics daily for up to 6 weeks and then as required during follow-up, as well as a 12-week supervised exercise program followed by a home exercise program.

Role of locking plates in treatment of difficult ununited fractures: a clinical study.

Objective: To present our experience in treatment of difficult ununited long bone fractures with locking plate.

Methods: Retrospective evaluation of locking plate fixation in 10 difficult nonunions of long bone fractures was done. Fixation was done with locking plate for femoral shaft fracture (3 patients), supracondylar fracture of femur (gap nonunion), fracture of clavicle, fracture of both forearm bones (radius and ulna) fracture of ulna, fracture of shaft of humerus, fracture of tibial diaphysis and supracondylar fracture of humerus (one patient each).

Association of GSTM1 and GSTT1 polymorphism with lipid peroxidation in benign prostate hyperplasia and prostate cancer: a pilot study.

Association of glutathione S-transferase (GST) M1 and T1 deletions with benign prostate hyperplasia (BPH) and prostate cancer is well reported. These enzymes metabolize numerous toxins thus protecting from oxidative injury. Oxidative stress has been associated with development of BPH and prostate cancer.

Polymorphisms in the P450 c17 (17-hydroxylase/17, 20-Lyase) gene: association with estradiol and testosterone concentration in hypospadias.

Objective: To investigate the association of CYP17 polymorphism with 17β-estradiol (E2) and testosterone (T) concentration in hypospadias.

Methods: Two-hundred twenty-three boys (91 with hypospadias and 132 age-matched controls) were included in the study. CYP17 polymorphism was evaluated using the polymerase chain reaction-restriction fragment length polymorphism method, whereas T and E2 levels were estimated in serum by enzyme-linked immunosorbent assay.

High prevalence of vitamin D deficiency in Asian-Indian patients with fragility hip fracture: a pilot study.

Objective: To assess vitamin D nutrition status in Asian-Indian patients with fragility hip fracture.

Methods: The study subjects included patients with non-traumatic hip fracture with age more than 50 years. Any patient who sustained fracture after road side accident of any severity was excluded.

Ipsilateral femoral neck and trochanter fracture.

Ipsilateral fractures in the neck and trochanteric region of the femur are very rare and seen in elderly osteoporotic patients. We present a case of a young man who presented with ipsilateral fracture of the femoral neck and a reverse oblique fracture in the trochanteric region following a motor vehicle accident. A possible mechanism, diagnostic challenge, and awareness required for identifying this injury are discussed.

A single incision surgical new anterior technique for forequarter amputation.

Background: Conventionally described standard techniques of forequarter amputation may not be suitable for patients presenting with neglected or maltreated very large tumors of the proximal humerus.

Patients And Methods: Eleven patients with unsalvageable malignant tumors of proximal humerus, who underwent forequarter amputation using a new technique between Jan 2008 to March 2010, were retrospectively analysed. This new single incision anterior approach involves supine positioning of patients, ligation of axillary vessels in the axilla followed by resection of muscles from lateral border and inferior angle of scapula, resection of lateral one-third of clavicle; resection of muscles from vertebral border and superior angle of scapula by applying superolateral traction without any incision over acromioclavicular axis or posterior scapular skin.

CYP 1A1 polymorphism and organochlorine pesticides levels in the etiology of prostate cancer.

Organochlorine pesticides (OCPs) and polymorphisms of xenobiotic metabolizing enzymes are reported to be associated with the possible risk of prostate cancer. OCPs are endocrine disruptors (EDs) which may act by disrupting the physiologic function of endogenous hormones and therefore possibly increase prostate cancer risk. CYP1A1 metabolizes several carcinogens and estrogens, etc.