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Effective management of complications from hyaluronic acid (HA) fillers is crucial in aesthetic medicine. This article examined the role of hyaluronidase in addressing adverse effects associated with HA fillers, such as nodules, vascular occlusions, and excessive volume. It highlights the enzyme's ability to degrade HA, thereby resolving issues that may arise from filler treatments. The discussion includes practical aspects of using hyaluronidase, such as recommended dosing, injection techniques, and potential risks. The benefits of hyaluronidase, including its rapid action in dissolving problematic fillers and its role in improving patient outcomes, are explored. The article also addresses limitations and safety considerations to provide a comprehensive understanding of hyaluronidase in the context of filler complications. By offering insights into the application and effectiveness of hyaluronidase, this article aimed to enhance practitioners' ability to manage HA filler-related issues effectively and ensure optimal results in aesthetic procedures.
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http://dx.doi.org/10.1097/GOX.0000000000006566 | DOI Listing |
Lasers Med Sci
September 2025
Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, 71 Hexi Street, Nanjing 210019, Jiangsu, China.
To evaluated the efficacy of photodynamic therapy (PDT) in improving laryngeal mucosal wound scar healing in vivo and investigated its underlying mechanisms. Laryngeal mucosal wounds were induced in Sprague-Dawley rats. Two weeks post-injury, PDT was administered via intraperitoneal injection of 100 mg/kg 5-aminolevulinic acid (5-ALA) and 635-nm red laser irradiation at varying energy doses (15, 30, and 45 J/cm²).
View Article and Find Full Text PDFJ Cosmet Dermatol
September 2025
Department of Dermatology, College of Medicine, Imam Mohammad Bin Saud University, Riyadh, Saudi Arabia.
Background: Necklines are a common complaint in patients as they are a sign of aging. Hyaluronic acid (HA) fillers are widely used to address volume loss and linear depressions. HA fillers are safe, effective, and versatile, but their use for necklines is not well-documented in the literature.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Spine Surgery, The 3rd Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, P. R. China.
Fibrotic scarring remains a critic obstacle to axonal regeneration after spinal cord injury (SCI). Current strategies primarily concentrating on eliminating extracellular matrix (ECM) components neglect their dispensable roles in maintaining tissue integrity. Here, it is reported that the mechanical strength of an integrated hydrogel composed of hyaluronic acid-graft-dopamine and HRR peptide directs fibroblast migration, determining ECM deposition.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
September 2025
Department of Orthopaedics, Hillel Yaffe Medical Center (HYMC), Hadera, Clinic, Tel-Aviv, Israel.
Purpose: This European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) formal consensus aims to provide evidence- and expert opinion-based recommendations for the use of point-of-care- and expanded-cell-based therapy (CBT) in the treatment of knee osteoarthritis (OA), focusing on indications, preparation, and administration.
Methods: A multidisciplinary group of 77 leading experts in musculoskeletal regenerative medicine from 22 European Countries formed a steering group, a rating group, and a reader group. The steering group developed 23 questions, originating from 27 statements.
ACS Biomater Sci Eng
September 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
The development of biomimetic scaffolds that emulate the extracellular matrix (ECM) is critical for advancing cell-based therapies and tissue regeneration. This study reports the formulation of CHyCoGel, a novel injectable, ECM-mimetic hydrogel scaffold composed of chitosan, hyaluronic acid, chondroitin sulfate, and an amphiphilic stabilizer. CHyCoGel addresses key limitations of existing scaffolds, offering improved structural uniformity, injectability, and gelation suitable for cell encapsulation and minimally invasive delivery.
View Article and Find Full Text PDF