Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This case describes a 46-year-old man presenting with epigastric pain, weight loss, and obstructive jaundice, initially misdiagnosed as pancreatic cancer due to a pancreatic head mass compressing the common bile duct. Intraoperative biopsies during an aborted Whipple procedure revealed coexisting autoimmune pancreatitis and Castleman disease. This case highlights the diagnostic challenges of Castleman disease, its potential association with autoimmune pancreatitis, and the critical role of histological analysis in differentiating it from malignancy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878988 | PMC |
| http://dx.doi.org/10.14309/crj.0000000000001635 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[18F]FDG PET/CT in pulmonary Castleman's disease.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
September 2025
Department of Nuclear Medicine, Sichuan Science City Hospital, Mianyang, Sichuan, China.
Unicentric Castleman disease treated with rituximab before surgery: clinicopathologic findings.
Ann Hematol
September 2025
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Castleman disease (CD) is a rare lymphoproliferative disorder with unique clinicopathological features, including two distinct clinical subtypes categorized as unicentric (UCD) and multicentric (MCD). UCD usually involves a single lymph node site presenting with no or minimal local symptoms. Histologically, most UCD cases exhibit regressive hyaline vascular germinal centers, characterized by penetrating vessels, dendritic hyperplasia/dysplasia, and increased interfollicular vascularity.
View Article and Find Full Text PDFHIV-Associated Multicentric Castleman Disease with Kaposi Sarcoma: A Case Report with 120-Week Follow-Up of HHV-8 After Remission.
J Infect Chemother
September 2025
AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
HIV-associated multicentric Castleman disease (HIV-MCD) is a rare, life-threatening lymphoproliferative disorder featuring systemic inflammation and marked lymphadenopathy. HIV-MCD is characterized by a human herpesvirus-8 (HHV-8) infection, with an increasing incidence despite advances in antiretroviral therapy (ART). Although HHV-8 viremia is a recognized indicator of disease recurrence, the necessity of intervention for low-level viremia reactivation remains unclear.
View Article and Find Full Text PDFCastleman disease with synchronous primary rectal and prostate cancers: a case report of successful multimodal treatment and 2-year recurrence-free survival.
Front Oncol
August 2025
Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Background: Castleman disease (CD) is a rare lymphoproliferative disorder associated with immune dysregulation that may increase the risk of malignancy. Synchronous multiple primary cancers are uncommon, and their etiology remains largely unclear. The coexistence of CD with synchronous multiple primary malignancies is exceptionally rare; therefore, the underlying mechanisms and optimal treatment strategies deserve further investigation.
View Article and Find Full Text PDFCaspase cleavage of Kaposi sarcoma-associated herpesvirus proteins: a role for K5 in preventing caspase-mediated cell death during lytic replication.
J Virol
August 2025
HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Viral infections lead to caspase activation as a cellular defense response. Some viruses overcome this response by encoding viral proteins that undergo caspase cleavage and, by various mechanisms, aid in cell survival. Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen acts as a pseudo-substrate for caspases-1 and -3, thereby interfering with the inflammatory and apoptotic response.
View Article and Find Full Text PDF