Article Synopsis
- The gut microbiota plays a crucial role in the onset and development of various human diseases, creating a complex interaction system related to intestinal health.
- The article discusses difficulties in studying the gut microbiota's impact on digestive diseases like metabolic dysfunction-associated steatotic liver disease (MASLD) and inflammatory bowel disease (IBD).
- It also highlights current treatment options (such as probiotics and fecal microbiota transplantation), new technologies (like gut microbiome-on-a-chip), and future research paths, emphasizing the need for ongoing testing of these approaches.
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Article Abstract
Accumulating evidence indicates that the gut microbiota is intricately involved in the initiation and progression of human diseases, forming a multidirectional regulatory axis centered on intestinal microbiota. This article illustrates the challenges in exploring the role of the gut microbiota in inflammatory digestive diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and inflammatory bowel disease (IBD), and summarizes the existing microbiome-focused treatment strategies (probiotics, prebiotics, symbiotics, fecal microbiota transplantation, and bacteriophages therapy), emerging technologies (gut microbiome-on-a-chip and artificial intelligence), as well as possible future research directions. Taken together, these therapeutic strategies and technologies present both opportunities and challenges, which require researchers and clinicians to test the rationality and feasibility of various therapeutic modalities in continuous practice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865350 | PMC |
| http://dx.doi.org/10.1002/imt2.265 | DOI Listing |
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