Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: We developed a new phantom for technical evaluation of jawbone single-photon emission computed tomography (SPECT) examinations for medication-related osteonecrosis of the jaw (MRONJ). In this study, we verified the utility of the phantom by determining optimal image reconstruction parameters.
Methods: We evaluated the image quality and quantification in jawbone SPECT images obtained by different reconstruction parameters using the phantom. The phantom images were acquired using a SPECT/computed tomography (CT) system and then reconstructed using ordered-subset expectation maximization (OSEM) iterative reconstruction with resolution recovery as well as scatter and attenuation correction with various update numbers and Gaussian filter full width at half maximums (FWHMs). The percent contrast (%contrast) and absolute recovery coefficient were calculated to determine the optimal reconstruction parameters (OSEM). Nineteen patients with a clinical diagnosis of MRONJ who underwent bone SPECT/CT were enrolled for the clinical study. The performance of OSEM was verified by comparison with OSEM determined by a spherical phantom, using the correlation between the mean standardized uptake value (SUV) and clinical staging and visual assessment as endpoints.
Results: In the phantom study, %contrast and absolute recovery coefficient increased with increasing update numbers. As the Gaussian filter FWHM increased, the quantitative accuracy and image sharpness decreased. The parameter determined by the phantom study (OSEM) recommended 120 updates and no filter. In the clinical study, the mean and standard deviation of SUV obtained from OSEM were 8.9 ± 1.4 for stage 1 lesions, 12.9 ± 4.1 for stage 2 lesions, and 13.8 ± 1.4 for stage 3 lesions. For OSEM, they were 5.4 ± 2.3 for stage 1 lesions, 8.3 ± 2.5 for stage 2 lesions, and 8.0 ± 0.9 for stage 3 lesions. The SUV obtained from OSEM had a stronger correlation with clinical stage. Based on visual assessment, the quality of the SPECT images reconstructed by OSEM (3.7 ± 0.9) was superior to that reconstructed by OSEM (2.9 ± 1.1).
Conclusions: We developed a novel phantom and adapted it for technical evaluation. This study demonstrated the utility of the developed phantom.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167234 | PMC |
| http://dx.doi.org/10.1007/s11282-025-00809-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic value of multiparameter [Ga]Ga-DOTA-FAPI-04 PET/MR imaging biomarkers for patients with advanced pancreatic cancer.
Eur J Nucl Med Mol Imaging
September 2025
Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Yang Pu District, Shanghai, 200433, China.
Purpose: In this retrospective study, whether [Ga]Ga-DOTA-FAPI-04 PET/MR imaging biomarkers can predict the progression-free survival (PFS) and overall survival (OS) of patients with advanced pancreatic cancer was investigated.
Methods: Fifty-one patients who underwent [Ga]Ga-DOTA-FAPI-04 PET/MR scans before first-line chemotherapy were recruited. Imaging biomarkers, including the maximum tumor diameter, minimum apparent diffusion coefficient (ADC), maximum and mean standardized uptake values (SUV and SUV), fibroblast activation protein- (FAP-) positive tumor volume (FTV and W-FTV) and total lesion FAP expression (TLF and W-TLF), were recorded for primary and whole-body tumors.
Preclinical Investigations Toward Gd-free Molecularly Targeted Dual-Modal, MRI Dynamic (DCE-MRI)/Optical Imaging Contrast Agent for Cardiac Angiosarcoma.
Top Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDFCell state dynamics during early stages of serous endometrial carcinoma.
J Pathol
September 2025
Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.
Serous endometrial carcinoma (SEC) is one of the most lethal types of uterine cancer, responsible for about 40% of all endometrial cancer-related deaths. Cell state dynamics during the early stages of SEC remain largely unknown, thereby hindering early detection and treatment of this disease. Here, we provide a comprehensive census of cell types and their states for normal, predysplastic, and dysplastic endometrium in a genetic mouse model of SEC.
View Article and Find Full Text PDFProteomic profiling and scRNA sequencing identify signatures associated with infection and risk of developing gastric cancer.
Cancer Biol Med
September 2025
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Objective: The key molecular events signifying the -induced gastric carcinogenesis process are largely unknown.
Methods: Bulk tissue-proteomics profiling were leveraged across multi-stage gastric lesions from Linqu ( = 166) and Beijing sets ( = 99) and single-cell transcriptomic profiling ( = 18) to decipher key molecular signatures of -related gastric lesion progression and gastric cancer (GC) development. The association of key proteins association with gastric lesion progression and GC development were prospectively studied building on follow-up of the Linqu set and UK Biobank ( = 48,529).
Kaposi sarcoma (KS) is an angioproliferative malignancy associated with human herpesvirus 8 (HHV-8) infection, predominantly affecting immunocompromised patients such as those with HIV/AIDS. Despite advances in antiretroviral therapy, KS remains a significant cause of morbidity and mortality in this population, especially when diagnosis or treatment is delayed. Ocular involvement, although rare, can lead to significant functional impairment.
View Article and Find Full Text PDF