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Article Abstract
We describe a paradigm wherein combined high TLS and low tissue-resident exhausted CD8+ T cells are required for optimal response to PD-1 blockade in RCC. This analysis identifies key determinants of response to PD-1 blockade in advanced RCC and suggests avenues for future immune modulation through rational combination therapy strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048281 | PMC |
| http://dx.doi.org/10.1158/2159-8290.CD-24-0991 | DOI Listing |
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