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Background And Objectives: In an era of rapid advances in research, it is imperative for residents to develop the skills for evidence-based practice. Alternative journal club formats grounded in active learning strategies may be better suited to address this need, although evidence is lacking. A theoretical framework of social cognitive learning theory (SCLT) may provide insight into how journal clubs can be better designed to teach residents how to evaluate research. Using a sequential, explanatory mixed-methods design and SCLT framework, we compared 2 different journal club formats for teaching methodology and clinical application. We also explored neurology resident experiences with both formats using a qualitative approach.
Methods: We conducted 4 alternating journal clubs: 2 active learning and 2 traditional. In the quantitative phase, we compared resident performance on presession and postsession assessments for the 2 different journal club formats. We designed parallel pretest and posttest forms and analyzed the change in scores using a linear mixed-effects model with fixed effects for the test type and pretest score. In the qualitative phase, we explored neurology resident experiences with both formats through the lens of SCLT. We observed the journal club sessions through an ethnographic lens and conducted semistructured one-on-one interviews with residents. The data were mixed during analysis of interview data.
Results: Resident participants (n = 18 active learning, 18 traditional) of each journal club completed pretests (n = 16 active learning, 11 traditional) and posttests (n = 8 active learning, 5 traditional). There were statistically significant increases in total (estimate = 18.03%, SD = 6.9, = 0.028) and clinical application (estimate = 48.40%, SD = 6.6, < 0.0001) pretest and posttest scores with the active learning format. There was no difference in methodology subscores (estimate = 5.84%, SD = 11.8, = 0.63). Regarding the active learning format, observations noted more demonstrations of retention, reproduction, and motivation during the sessions than a traditional format. Interviews highlighted 4 main themes: the burden of preparation, the importance of clinical relevance, preference for organic discussion, and the value of faculty expertise.
Discussion: These results highlight the strengths and disadvantages of a more discussion-based journal club format. Further altering the design to a "no-prep" approach and emphasizing the faculty facilitator's role may further optimize teaching of evidence-based practice.
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http://dx.doi.org/10.1212/NE9.0000000000200195 | DOI Listing |
Cell Physiol Biochem
September 2025
Department of Histology and Embryology and Vascular Biology Student Research Club, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland, E-Mail:
Migrasomes are newly discovered, migration-dependent organelles that mediate the release of cellular contents into the extracellular environment through a process known as migracytosis. Since their identification in 2014, growing evidence has highlighted their critical roles in intercellular communication, organ development, mitochondrial quality control, and disease pathogenesis. Migrasome biogenesis is a complex, multi-step process tightly regulated by lipid composition, tetraspanin-enriched microdomains, and molecular pathways involving sphingomyelin synthase 2, Rab35, and integrins.
View Article and Find Full Text PDFRen Fail
December 2025
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Biological sex has a profound impact on disease severity, outcomes and diagnosis yet, its role in clinical disease is insufficiently explored. Acute on chronic liver failure (ACLF) is associated with high mortality and multiple organ dysfunctions, where acute kidney injury (AKI) significantly worsens prognosis. Here we investigated the impact of sex on the diagnostic parameters used for severity grading in ACLF.
View Article and Find Full Text PDFTheriogenology
August 2025
Department of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, 1870, Frederiksberg C, Denmark.
Dystocia is a common problem in dogs. It is often resolved by emergency caesarean section, which is an invasive procedure that poses a risk to the dam and her puppies, and can cause postoperative discomfort. The risk of death to both puppies and dams can be decreased by elective caesarean section in bitches with a high risk of dystocia.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, China.
Background: RUNX3 acts as a tumor suppressor gene in non-small-cell lung cancer (NSCLC), yet its specific biological mechanism is still unclear. This study aimed to uncover tumor microenvironment (TME) changes in NSCLC with varying RUNX3 expression statuses through single-cell RNA sequencing.
Patients And Methods: In total, seven patients with NSCLC with detailed pathological data were involved, with three both paracancerous and cancerous tissue samples.
J Prof Nurs
September 2025
York College of Pennsylvania, 441 County Club Road, York, PA 17403, United States of America. Electronic address:
Background: Despite decades of initiatives to increase nursing workforce diversity, gaps persist between patient population and nursing workforce demographics.
Problem: Emphasis on NCLEX pass rates as a program quality indicator, combined with systemic barriers, creates complex challenges that influence admission and progression policies in nursing education. Evidence suggests these factors disproportionately affect underrepresented minority (URM) students, impacting both academic success and workforce diversity.