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Article Abstract
Here, a novel strategy for the preparation of ultra-stable gold nanoparticles was developed based on a core-shell structure of single-molecule micelles, which offered advantages such as convenience, rapid preparation, size control. These ultra-stable gold nanoparticles enable specific miRNA detection, facilitating the precise screening of tumor cells.
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Article Synopsis
- Colloidal gold nanoparticles (AuNPs) are typically synthesized using heated or boiling water with HAuCl and sodium citrate, but high temperatures can lead to particle aggregation.
- This study introduces a new method for creating ultra-stable AuNPs using citric acid, dihydrolipoic acid, and dihydrolipoic acid-alanine, which allows for rapid synthesis under UV light at room temperature.
- The research examines how various factors like reaction time, temperature, and pH influence AuNP formation and stability, and demonstrates the AuNPs' ability to efficiently catalyze the reduction of 4-nitrophenol to 4-aminophenol.