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As a successor to the DArk Matter Particle Explorer (DAMPE), the Very Large Area γ-rays Space Telescope (VLAST) is being designed to strengthen γ-ray observations and extend the cosmic ray nuclei measurements up to Zr (Z = 40) and even heavier ions. Consequently, a large dynamic range is required by the charge detector of VLAST to cover the measurements of cosmic ray particles from the proton to ultra-heavy ions. To achieve the requirements, a readout design based on the three dynodes signal extracted from the photomultiplier tube has been proposed. In addition, a prototype VLAST charge detector has been developed and tested with cosmic rays, pulse UV laser, and relativistic heavy ion beams to verify this design. The test results illustrate that the dynamic range readout design can easily cover the required dynamic range of about five orders of magnitude.
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http://dx.doi.org/10.1063/5.0238224 | DOI Listing |
Med Oncol
September 2025
Venom and Biotherapeutics Molecules Laboratory, Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Neuropeptide Y (NPY) and the voltage-gated potassium channel Kv1.3 are closely associated with breast cancer progression and apoptosis regulation, respectively. NPY receptors (NPYRs), which are overexpressed in breast tumors, contribute to tumor growth, migration, and angiogenesis.
View Article and Find Full Text PDFWien Klin Wochenschr
September 2025
3rd Medical Department with Cardiology and Intensive Care Medicine, Clinik Ottakring (Wilhelminenhospital), Montleartstraße 37, 1160, Vienna, Austria.
Background: Acute heart failure (AHF) significantly contributes to cardiovascular morbidity and mortality, bearing a substantial socioeconomic burden. While the dynamics of chronic heart failure have been extensively explored in global patient cohorts, comprehensive data specific to AHF remain limited.
Methods: This retrospective, single-center, real-world study comprises hospitalized patients with AHF, admitted to a tertiary care hospital in Vienna, Austria, between 1 January 2012 and 31 December 2019.
Pain
August 2025
Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
The thermal grill, in which innocuous warm and cool stimuli are interlaced, can produce a paradoxical burning pain sensation-the thermal grill illusion (TGI). Although the mechanisms underlying TGI remain unclear, prominent theories point to spinal dorsal horn integration of innocuous thermal inputs to elicit pain. It remains unknown whether the TGI activates peripheral nociceptors, or solely thermosensitive afferents that are integrated within the spinal cord to give rise to a painful experience.
View Article and Find Full Text PDFAppl Environ Microbiol
September 2025
DGIMI, Université de Montpellier, INRAE, Montpellier, France.
is an entomopathogenic bacterium involved in a mutualistic relationship with nematodes. produces a multitude of specialized metabolites by non-ribosomal peptide synthetase (NRPS) pathways to mediate bacterium-nematode-insect interactions. PAX cyclolipopeptides are a family of NRP-type molecules whose ecological role remains poorly understood.
View Article and Find Full Text PDFJ Chem Phys
September 2025
School of Mathematical and Physical Sciences, University of Sheffield, Hicks Building, Hounsfield Road, Sheffield S3 7RH, United Kingdom.
The development of the microstructure during polymeric spinodal decomposition can be monitored in real time using small-angle scattering. Information about the microstructure can be deduced from measurements of the structure factor-a quantity directly proportional to the scattered intensity. While the time evolution of the structure factor can be measured relatively easily, modeling it has proved to be much more difficult.
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