Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Volatile organic compounds (VOCs) are pervasive environmental pollutants known to impact human health, but their role in liver steatosis or fibrosis is not fully understood. This study investigates the association of urinary VOC mixtures with the risk of liver steatosis and fibrosis in U.S. adult population.
Methods: Data of 1854 adults from the National Health and Nutrition Examination Survey (NHANES) from 2017.01 to 2020.03 were collected. Vibration Controlled Transient Elastography (VCTE) assessed hepatic steatosis and liver fibrosis via the controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), respectively. The study examined the relationship between urinary exposure biomarkers for 20 VOCs and liver health outcomes using multivariate logistic regression and Bayesian Kernel Machine Regression (BKMR) to evaluate the effects of both individual and mixed VOC exposures.
Results: Multivariate logistic regression analysis revealed that exposure biomarkers for acrolein and crotonaldehyde were positively associated with hepatic steatosis. Conversely, biomarkers for styrene, ethylbenzene, and propylene oxide were negatively associated with hepatic steatosis. Furthermore, biomarkers for 1,3-butadiene and xylene were positively associated with liver fibrosis, while ethylbenzene was negatively associated with this condition. BKMR analysis identified a significant positive joint effect of VOC biomarkers on CAP. Notably, when other VOC-EBs were held at median levels, biomarkers for acrolein and 1,3-butadiene exhibited linear correlations with Ln CAP and hepatic Ln LSM, respectively.
Conclusion: The study highlights the potential hepatotoxic effects of VOC mixtures, particularly noting the roles of acrolein and 1,3-butadiene in exacerbating liver steatosis and fibrosis. These findings advocate for further research to explore the mechanistic pathways and conduct longitudinal studies to establish causality and enhance understanding of VOCs' impact on liver health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782259 | PMC |
| http://dx.doi.org/10.3389/fpubh.2024.1437519 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-Omics Analysis Revealed Characterization of Gastric Microbiome and Metabolome in Helicobacter pylori-Induced Progression of MASLD.
Helicobacter
September 2025
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Several clinical studies have demonstrated that Helicobacter pylori (Hp) infection may exacerbate the progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD); however, the underlying mechanisms remain unclear. This study aims to investigate the characterization of the gastric microbiome and metabolome in relation to the progression of MASLD induced by Hp infection.
Methods: We established a high-fat diet (HFD) obese mouse model, both with and without Hp infection, to compare alterations in serum and liver metabolic phenotypes.
7-Ketocholesterol as a Critical Oxysterol: Impact on Human Health and Safety in Food Systems.
J Steroid Biochem Mol Biol
September 2025
Biochemistry and Phytochemistry Research Division, Jubilee Centre for Medical Research, Thrissur, Kerala, 680005, India. Electronic address:
7-Ketocholesterol (7-KC) is a biologically active oxysterol formed through the oxidation of cholesterol, predominantly under conditions of oxidative stress. It is generated both enzymatically in specific tissues such as the brain and liver, and non-enzymatically via reactive oxygen species (ROS), especially in aging tissues and heat-processed animal-derived foods. 7-KC exerts multifaceted effects on human health, extending beyond lipid metabolism to disrupt glucose and amino acid utilization, impair mitochondrial function, and provoke endoplasmic reticulum (ER) stress.
View Article and Find Full Text PDFTHE HIDDEN IMPACT OF INTRAUTERINE GROWTH RESTRICTION IN THE PATHOGENESIS OF METABOLIC SYNDROME: FUNCTIONAL AND STRUCTURAL ALTERATIONS IN RAT VISCERAL ADIPOSE TISSUE.
J Nutr Biochem
September 2025
Department of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:
Background: Individuals born after intrauterine growth restriction (IUGR) have a higher risk of developing metabolic syndrome (MetS) in adulthood. In a rat model, male IUGR offspring exhibit MetS features-including elevated systolic blood pressure, glucose intolerance, non-alcoholic fatty liver disease, and increased visceral adipose tissue (VAT)-by 6 months of age. Female offspring, however, do not.
View Article and Find Full Text PDFPlant sterol ester of α-linolenic acid protects against ferroptosis in metabolic dysfunction-associated fatty liver disease via activating the Nrf2 signaling pathway.
J Nutr Biochem
September 2025
Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Wuhan 430062, PR CHINA
Increasing evidence indicates that ferroptosis contributes to the occurrence and development of metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to investigate the improvement effect of plant sterol ester of α-linolenic acid (PS-ALA) on ferroptosis in hepatocytes and further elucidate the underlying molecular mechanism, focusing on the regulation of Nrf2 signaling. We found that PS-ALA ameliorated liver iron overload and reduced ROS generation and lipid peroxides (MDA and 4-HNE) production both in mice fed a high-fat diet and HepG2 cells induced by oleic acid/erastin.
View Article and Find Full Text PDFAssociation between mixed oil lipid emulsions and all-cause infections relative to soybean oil lipid emulsions in hospitalized adults: A retrospective cohort study.
JPEN J Parenter Enteral Nutr
September 2025
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.
Background: Intravenous lipid emulsions are a key component of parenteral nutrition, and their fatty acid compositions may influence immune responses and clinical outcomes.
Methods: This retrospective cohort study conducted from January 2020 to December 2022 compared clinical outcomes of hospitalized non-critical care patients receiving parenteral nutrition with either mixed oil or soybean oil lipid emulsions for at least 48 h. The primary outcome was a composite of the presence of pneumonia, urinary tract infection, or an intra-abdominal collection diagnosed within 14 days of initiating parenteral nutrition.