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Wave mixing (WM) techniques are crucial for applications such as supercontinuum generation, frequency conversion, and high-dimensional quantum encoding. However, their efficiency is often limited by complex phase-matching requirements, and current insights into phase-matching mechanisms for high-order WM remain limited. To address this, compact optical path configurations with high-peak-power, synchronous, multicolor ultrafast laser sources are needed to enhance high-order wave-mixing efficiency. This study presents a quad-wavelength synchronously mode-locked bulk laser using a Fabry-Perot structured (FPS) crystal. By employing a Yb:SYB/Yb:CNGS FPS crystal, we achieved quad-wavelength synchronous mode-locking operation at 1042.6, 1044.7, 1046.9, and 1049.1 nm in a single-cavity without additional wavelength selection elements. The FPS crystal serves as both the gain medium and a spectral filter, simplifying the laser system. The mode-locked FPS crystal lasers offer new possibilities for developing multi-wavelength light sources.
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http://dx.doi.org/10.1364/OE.549717 | DOI Listing |
Proc Natl Acad Sci U S A
August 2025
Department of Chemistry, Oregon State University, Corvallis, OR 97331.
Fluorescent proteins (FPs) are noninvasive genetically encodable probes that have revolutionized bioimaging and health fields with vivid images and an ever-growing repertoire from jellyfish to sea anemones and corals. Inside the protein matrix, chromophore nonplanarity and flexibility have long been argued to govern the fluorescence efficiency of FPs, yet their fundamental roles and relative importance have been elusive which hinder the rational design of versatile FPs and biosensors. Herein, we tackle this central question by investigating two recently engineered FP-based turn-on chloride (Cl) sensors, ChlorON1 and 3, using an ultrafast electronic and vibrational spectroscopic toolset together with advanced multireference simulations for both structure and spectrum.
View Article and Find Full Text PDFBMC Microbiol
July 2025
Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October, Egypt.
Filamentous phages (FPs) have been recently isolated from Acinetobacter baumannii. While FPs are known to modulate the virulence of some Gram-negative pathogens, their role in A. baumannii has not been fully explored.
View Article and Find Full Text PDFACS Nano
August 2025
Nanostructures Research Laboratory, Japan Fine Ceramics Center, Nagoya, Aichi 456-8587, Japan.
Atomic-scale in situ characterization techniques are necessary to clarify the dynamic local structural changes during intercalation reactions. High-resolution transmission electron microscopy (HRTEM) is at the forefront of this field. However, the image contrast in HRTEM is not always straightforward, necessitating the exploration of alternative imaging techniques.
View Article and Find Full Text PDFOpt Express
September 2024
Phase measuring deflectometry (PMD) has been extensively applied to measure specular surfaces due to its non-contact, high-precision, full-field measurement capabilities. Liquid crystal display (LCD) screen is the most common structured light source in PMD. However, the response time of liquid crystal molecules limits its frame rate to around 100 frames per second (fps).
View Article and Find Full Text PDFAdv Mater
June 2025
Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich, Sonneggstrasse 3, Zurich, 8092, Switzerland.
Expanding fluorescence bioimaging into the second near-infrared spectrum (NIR-II, 1000-1700 nm) unlocks advanced possibilities for diagnostics and therapeutics, offering superior tissue penetration and resolution. 2D copper tetrasilicate (CTS) pigments (MCuSiO, M = Ca, Sr, Ba) are known for their brightness and stability, yet synthetic challenges have curbed their integration into bioimaging. Here, flame-spray-pyrolysis (FSP) is introduced as a versatile and scalable synthesis approach to produce ultra-bright, metastable CTS nanosheets (NS) by annealing multi-element metal oxide nanoparticles into 2D crystals through calcination or laser irradiation.
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