Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Covalent organic frameworks (COFs), known for the precise tunability of molecular structures, hold significant promise for photocatalytic hydrogen peroxide (HO) production. Herein, by systematically altering the quinoline (QN) linkages in triazine (TA)-based COFs via the multi-component reactions, six R-QN-TA-COFs are synthesized with identical skeletons but different substituents. The fine-tuning of the optoelectronic properties and local microenvironment of COFs is allowed, thereby optimizing charge separation and improving interactions with dissolved oxygen. Consequently, MeO-QN-TA-COF is customized to achieve an impressive rate of HO production up to 7384 µmol g⁻ h⁻ under an air atmosphere in water without any sacrificial agents, surpassing most of the reported COF photocatalysts. Its high stability is demonstrated through five consecutive recycling experiments and the characterization of the recovered COF. The reaction mechanism for the HO production is further investigated using a suite of quenching experiments, in situ spectroscopic analysis, and theoretical calculations. The enhanced photocatalytic HO production over MeO-QN-TA-COF is through 2e⁻ oxygen reduction reaction and water oxidation reaction pathways. Overall, the crucial role of linkage microenvironment modulation in the design of COFs for solar-driven effective photocatalytic HO production.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/smll.202411625 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity.
Cancer Res
September 2025
The Wistar Institute, Philadelphia, PA, United States.
Parkin is a mitochondria-associated E3 ubiquitin (Ub) ligase that mediates mitophagy and organelle quality control. More recently, Parkin has been implicated in stimulating antitumor immunity and reprogramming the tumor immune microenvironment. Here, we showed that Parkin ubiquitinates the alarmin molecule, high mobility group box-1 (HMGB1) on Lys146 (K146) using predominantly K48 linkages.
View Article and Find Full Text PDFA pH-responsive polycarbonate nanoplatform enables sequential drug release for enhanced apoptotic cascade synergy in non-small cell lung cancer therapy.
Acta Biomater
September 2025
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China; Shenzhen Institute of Wuhan University of Technol
Tumor heterogeneity poses formidable challenges to effective cancer therapy, necessitating the implementation of combination regimens to achieve enhanced antitumor efficacy. Optimizing drug administration sequences is pivotal to harnessing synergistic effects and achieving superadditive therapeutic outcomes (1 + 1 > 2). Erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, dynamically reprograms apoptotic pathways, sensitizing tumor cells to subsequent DNA-damaging agents like doxorubicin within a defined temporal window, thereby augmenting chemotherapy efficacy.
View Article and Find Full Text PDFSite-specific engineering of S-Te-S bridged nano-prodrug: A dual equilibrium strategy for enhanced antitumor efficacy and safety of paclitaxel.
J Control Release
August 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China. Electronic address:
Homodimeric prodrug nanoassemblies (HPNs) have emerged as an effective strategy to enhance the therapeutic efficacy and safety of chemotherapeutic drugs. However, achieving both stable assembly and rapid drug release in tumor remains a critical challenge. Herein, we designed S-Te-S linkages with varying linkage lengths (α-, β-, and γ-) to develop three paclitaxel (PTX) homodimeric prodrug nanoassemblies (PHPNs).
View Article and Find Full Text PDFA TME-responsive polysaccharide nanoplatform integrating synergetic therapy for cancer.
Int J Biol Macromol
August 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China. Electronic address:
A self-assembling nanoplatform based on FOB (a heteropolysaccharide from Fomitopsis officinalis) named QU@FOB-FcDBA was developed in this study. A dynamic boronate ester bond, a pH-sensitive covalent linkage formed through reversible dehydration reactions, linked FOB and 1,1'-ferrocenediboronic acid (FcDBA) while encapsulating the hydrophobic drug quercetin (QU). The formulation not only enhanced the water solubility of QU, but also indirectly improved the clinical utilization rate of QU.
View Article and Find Full Text PDFAdvancing Spherical Nucleic Acid Synthesis in Less-Polar Solvents.
Small
August 2025
Hefei National Research Center for Physical Sciences at the Microscale, Center for Bioanalytical Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Spherical nucleic acids (SNAs) are radially packed, highly dense DNA "forests" on nanoparticle cores, depicting a useful class of artificially engineered bionanomaterials. The widespread uses of SNAs in diverse chemistry and nanotechnology areas have driven their synthetic innovations toward reduced time/cost and ever-improved quality. Different from existing methods based on salt-aging, low-pH, freezing, and dehydration conditions, herein a speedy and facile way is reported to produce SNAs in miscible aqueous-alcoholic media with easily adjustable solvent polarities.
View Article and Find Full Text PDF