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http://dx.doi.org/10.4274/balkanmedj.galenos.2024.2024-9-3.response | DOI Listing |
J Cardiovasc Pharmacol
September 2025
Department of Cardiovascular Medicine, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430060, China.
Nuclear factor erythrocyte 2-associated factor 2 (Nrf2) is an important transcriptional regulator that plays a protective role in myocardial remodeling. Omaveloxolone (Omav) acts as an activator of Nrf2 and plays a protective role by decreasing oxidative stress and inflammation. The purpose of this study was to explore the role of Omav in myocardial remodeling and investigate the potential mechanism involved.
View Article and Find Full Text PDFClin Genet
September 2025
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang Province, People's Republic of China.
Congenital microcoria (MCOR) is a rare inherited ocular disorder. Here, we describe a novel nonsense variant in the CPAMD8 gene in a patient with MCOR. We conducted a comprehensive clinical examination of a patient diagnosed with MCOR and performed whole-exome sequencing to identify potential pathogenic variants.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Fitzpatrick Referrals, Neurology Service, Eashing, United Kingdom.
Pug dogs are predisposed to thoracolumbar myelopathy associated with vertebral articular process dysplasia, suggesting a biomechanical etiology. While surgery is commonly pursued, long-term outcomes remain poorly defined. This retrospective descriptive case series reports on seven Pug dogs that underwent surgical treatment for thoracolumbar myelopathy and were followed up for at least 7 years postoperatively.
View Article and Find Full Text PDFSoft Matter
September 2025
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0905, USA.
Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M.
View Article and Find Full Text PDFJ Neurochem
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Orofacial neuropathic pain, a debilitating condition associated with trigeminal nerve injury, is often characterized by allodynia. N-methyl-d-aspartate receptors (NMDARs), particularly the GluN1 subunit, play a central role in mediating this pain. The GluN1 subunit undergoes alternative splicing at exon 5, generating isoforms GluN1a (lacking the exon 5-encoded N1 cassette) and GluN1b (retaining the N1 cassette), which have distinct functional roles.
View Article and Find Full Text PDF