98%
921
2 minutes
20
Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M. K. Raihan , , 2021, , 9198-9209) and depth (M. K. Raihan , , 2022, , 7427-7440), we investigate here the flow responses to changing constriction width and in turn contraction ratio, CR, of the main channel width to the constriction width in planar constriction microchannels. We test water and three polymer solutions including shear thinning xanthan gum, viscoelastic polyethylene oxide (PEO), and shear thinning/viscoelastic polyacrylamide solutions. Overall, the contraction and expansion flows in all tested fluids demonstrate destabilization with increasing CR except for the PEO solution, where the threshold Reynolds number for the onset of contraction flow instability first increases and then decreases. Such nonmonotonic CR dependence is also observed from the vortex length in the contraction PEO flow. In contrast, the vortex length for every other case has a fixed-order (either zero or a positive number based on fluid rheology) dependence on CR. The insights obtained here will benefit the designing of lab-on-a-chip devices as well as the harnessing of pore-scale flows for enhanced mixing, material recovery and sequestration purposes.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d5sm00688k | DOI Listing |
Soft Matter
September 2025
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0905, USA.
Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M.
View Article and Find Full Text PDFBiol Open
August 2025
Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Diversin is a vertebrate homolog of the core planar cell polarity (PCP) protein Diego. Here we studied the function of Diversin in Xenopus embryo morphogenesis and its subcellular localization at different locations in superficial ectoderm cells. Depletion of Diversin in the neuroectoderm inhibited apical domain size and neural tube closure and disrupted the polarized localization of endogenous Vangl2, another PCP protein.
View Article and Find Full Text PDFDiversin is a vertebrate homolog of the core planar cell polarity (PCP) protein Diego. Here we studied the function of Diversin in Xenopus embryo morphogenesis and its subcellular localization at different locations in superficial ectoderm cells. Depletion of Diversin in the neuroectoderm inhibited apical domain size and neural tube closure and disrupted the polarized localization of endogenous Vangl2, another PCP protein.
View Article and Find Full Text PDFCurr Biol
July 2025
Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA. Electronic address:
Planar cell polarity (PCP) is a phenomenon of coordinated cell orientation in many epithelia and is required for early morphogenetic events, such as vertebrate gastrulation or neural tube closure, that place embryonic tissues in their proper locations. Known PCP complexes segregate to opposite edges of each cell due to regulatory feedback interactions; however, whether and how PCP is connected to the tension-sensing machinery has been elusive. Here, we observed dynamic polarization of afadin- and α-actinin-interacting protein (ADIP) in the epithelia adjacent to the involuting marginal zone and the folding neural plate of Xenopus embryos, suggesting that it is controlled by mechanical cues.
View Article and Find Full Text PDFUnlabelled: Planar cell polarity (PCP) is a phenomenon of coordinated cell orientation in many epithelia and is required for early morphogenetic events, such as vertebrate gastrulation or neural tube closure that place embryonic tissues in their proper locations. Known PCP complexes segregate to opposite edges of each cell due to regulatory feedback interactions, however, whether and how PCP is connected to the tension-sensing machinery has been elusive. Here we observed dynamic polarization of Afadin- and α-Actinin-interacting protein (ADIP) in the epithelia adjacent to the involuting marginal zone and the folding neural plate of embryos, suggesting that it is controlled by mechanical cues.
View Article and Find Full Text PDF