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Methods to prepare and characterize neutron helical waves carrying orbital angular momentum (OAM) were recently demonstrated at small-angle neutron scattering (SANS) facilities. These methods enable access to the neutron orbital degree of freedom which provides new avenues of exploration in fundamental science experiments as well as in material characterization applications. However, it remains a challenge to recover phase profiles from SANS measurements. We introduce and demonstrate a novel neutron interferometry technique for extracting phase information that is typically lost in SANS measurements. An array of reference beams, with complementary structured phase profiles, are put into a coherent superposition with the array of object beams, thereby manifesting the phase information in the far-field intensity profile. We demonstrate this by resolving petal-structure signatures of helical wave interference for the first time: an implementation of the long-sought recovery of phase information from small-angle scattering measurements.
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http://dx.doi.org/10.1038/s41467-024-54991-8 | DOI Listing |
Langmuir
September 2025
Centre québécois sur les matériaux fonctionnels/Quebec Centre for Advanced Materials (CQMF/QCAM), Chemistry Department, 801 Sherbrooke St. W., Montreal, Québec H3A 0B8, Canada.
Poly(γ-stearyl-l-glutamate) (PSLG) is a semiflexible synthetic polypeptide that forms both thermotropic and lyotropic liquid crystal (LC) phases. We previously showed that spherical nanoparticles (NPs) decorated with another semiflexible helical polymer, poly(hexyl isocyanate), form lyotropic nematic rather than cubic LC phases. In this work, PSLG ligands for functionalizing 4 nm ZrO NPs were prepared via N-carboxyanhydride ring-opening polymerization.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Pacific Northwest National Laboratory, Richland, Washington 99354, United States.
Water-ion interactions govern the physicochemical properties of aqueous solutions, impacting the structure of the hydrogen bonding network and ion diffusivities. To elucidate these effects under alkaline conditions relevant to diverse application spaces, we examined NaOD-DO solutions using two-dimensional infrared spectroscopy (2D-IR), small-angle X-ray scattering (SAXS), and nuclear magnetic resonance spectroscopy (NMR). Vibrational energy transfer between the donor anion SeCN, used as a 2D-IR probe, and the acceptor anion OD was used to track the average separation distance of ions in the DO solutions, while SAXS and NMR experiments measured the structure of the bulk DO solvent.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Institute of Pharmaceutical Science, King's College London, Franklin Wilkins Building, Stamford Street, London, SE1 9NH, UK.
As supramolecular assemblies, polypseudorotaxanes (PPR) exhibit inherent advantages in modular adaptability and structural programmability, with the potential to build tuneable platforms integrating various functionalities. Here we report the "one-pot" preparation of a self-assembled thiol-rich PPR (SPPR), where thiolated-α-cyclodextrins (SHαCD) spontaneously thread onto polymers, and are then crosslinked into a three-dimensional network by the thermally-triggered oxidation of thiols into disulfide bonds. The dynamic thiol groups along the SPPR provide remarkable modularity for the functionalization of thiophilic metal nanoparticles (NPs), exemplified by two application vectors.
View Article and Find Full Text PDFBiophys J
September 2025
Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton T6G 2E1, Alberta, Canada; Department of Microbiology, Immunology
The dengue virus (DENV) poses a significant threat to human health, accounting for approximately 400 million infections each year. Its genome features a circular structure that facilitates replication through long-range RNA-RNA interactions, utilizing cyclization sequences located in the untranslated regions (UTRs). To gain new insights into the organization of the DENV genome, we purified the 5' and 3' UTRs of DENV in vitro and examined their structural and binding properties using various biophysical techniques combined with computational methods.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
School of Physics, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. Electronic address:
Keratins represent an important class of sulfur-rich structural proteins. In this study, the pressure response of α-keratin, extracted from sheep wool, was investigated using Raman spectroscopy up to 4 GPa. A non-polar liquid (a Fluorinert™ FC70/77 mixture) served as the Pressure Transmitting Medium (PTM) in a Diamond Anvil Cell (DAC).
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