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Article Abstract
Lysosomes are acidic membrane-bound organelles that aid digestion, excretion, and cell renewal. The lysosomal membranes are essential for maintaining lysosomal functions and cellular homeostasis. In this work, we developed a molecular "NOR" logic gate, , by introducing malachite green into the spirocyclic rhodamine. requires restriction of molecular rotation of the malachite green motif (, tight membrane structure) and a large amount of H ions to convert the spirocyclic rhodamine into the zwitterionic form (, acidic environment) to produce a fluorescent product (), providing a fluorogenic probe to visualize the lysosomal membrane dynamics in living cells with subdiffraction resolution by using HyVolution (also known as Lightning), an unconventional and inexpensive super-resolution imaging approach based on a basic confocal optical system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740186 | PMC |
| http://dx.doi.org/10.1021/acs.analchem.4c05907 | DOI Listing |
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