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Remote sensing images play a vital role in domains including environmental monitoring, agriculture, and autonomous driving. However, the detection of targets in remote sensing images remains a challenging task. This study introduces innovative methods to enhance feature extraction, feature fusion, and model optimization. The Adaptive Selective Feature Enhancement Module (AFEM) dynamically adjusts feature weights using GhostModule and sigmoid functions, thereby enhancing the accuracy of small target detection. Moreover, the Adaptive Multi-scale Convolution Kernel Feature Fusion Module (AKSFFM) enhances feature fusion through multi-scale convolution operations and attention weight learning mechanisms. Moreover, our proposed ARSOD-YOLO optimized the network architecture, component modules, and loss functions based on YOLOv8, enhancing outstanding small target detection capabilities while preserving model efficiency. We conducted experiments on the VEDAI and AI-TOD datasets, showcasing the excellent performance of ARSOD-YOLO. Our algorithm achieved an mAP50 of 74.3% on the VEDAI dataset, surpassing the YOLOv8 baseline by 3.1%. Similarly, on the AI-TOD dataset, the mAP50 reached 47.8%, exceeding the baseline network by 6.1%.
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http://dx.doi.org/10.3390/s24237472 | DOI Listing |
Mutat Res Rev Mutat Res
September 2025
Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:
To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.
View Article and Find Full Text PDFJCO Precis Oncol
September 2025
Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA.
Purpose: mutations are classically seen in non-small cell lung cancers (NSCLCs), and EGFR-directed inhibitors have changed the therapeutic landscape in patients with -mutated NSCLC. The real-world prevalence of -mutated ovarian cancers has not been previously described. We aim to determine the prevalence of pathogenic or likely pathogenic mutations in ovarian cancer and describe a case of -mutated metastatic ovarian cancer with a durable response to osimertinib, an EGFR-directed targeted therapy.
View Article and Find Full Text PDFJ Leukoc Biol
September 2025
Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av. 25 de Julio 965, Villa de San Sebastián, 28045 Colima, México.
Ion channels are integral membrane proteins which facilitate rapid transport of small ions into and out of the cell and between organelles and cytosol. Cytolytic lymphocytes including natural killer (NK) cells principally kill virus-infected and cancer cells by releasing cytolytic granules within the immunological synapse, formed between target and effector cells. This process strongly depends on Ca2+ signaling, which in human NK cells is controlled by the phospholipase C (PLCγ)/inositol-1,4,5-triphospate receptor (IP3R)/calcium release-activated calcium channel (CRAC) axis.
View Article and Find Full Text PDFGerontologist
September 2025
Department of Child Development and Family Studies, College of Human Ecology, Seoul National University, Seoul, South Korea.
Background And Objectives: Volunteering has cognitive benefits in later life and has been theorized to protect against Alzheimer's disease and related dementias (ADRD). A small but growing body of volunteer programs target people with mild cognitive impairment (MCI)-who are presumably at elevated risk for ADRD, but we know surprisingly little about who volunteers with MCI and how volunteering affects their subsequent cognitive changes. The current study sought to address these gaps.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Smart Manufacturing, Industrial Perception and Intelligent Manufacturing Equipment Engineering Research Center of Jiangsu Province, Nanjing Vocational University of Industry Technology, Nanjing, Jiangsu, China.
In the field of quality control, metal surface defect detection is an important yet challenging task. Although YOLO models perform well in most object detection scenarios, metal surface images under operational conditions often exhibit coexisting high-frequency noise components and spectral aliasing background textures, and defect targets typically exhibit characteristics such as small scale, weak contrast, and multi-class coexistence, posing challenges for automatic defect detection systems. To address this, we introduce concepts including wavelet decomposition, cross-attention, and U-shaped dilated convolution into the YOLO framework, proposing the YOLOv11-WBD model to enhance feature representation capability and semantic mining effectiveness.
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