98%
921
2 minutes
20
At CRYPTO 2019, Gohr pioneered the application of deep learning to differential cryptanalysis and successfully attacked the 11-round NSA block cipher Speck32/64 with a 7-round and an 8-round single-key differential neural distinguisher. Subsequently, Lu et al. (DOI 10.1093/comjnl/bxac195) presented the improved related-key differential neural distinguishers against the SIMON and SIMECK. Following this work, we provide a framework to construct the enhanced related-key differential neural distinguisher for SIMON and SIMECK. In order to select input differences efficiently, we introduce a method that leverages weighted bias scores to approximate the suitability of various input differences. Building on the principles of the basic related-key differential neural distinguisher, we further propose an improved scheme to construct the enhanced related-key differential neural distinguisher by utilizing two input differences, and obtain superior accuracy than Lu et al. for both SIMON and SIMECK. Specifically, our meticulous selection of input differences yields significant accuracy improvements of 3% and 1.9% for the 12-round and 13-round basic related-key differential neural distinguishers of SIMON32/64. Moreover, our enhanced related-key differential neural distinguishers surpass the basic related-key differential neural distinguishers. For 13-round SIMON32/64, 13-round SIMON48/96, and 14-round SIMON64/128, the accuracy of their related-key differential neural distinguishers increases from 0.545, 0.650, and 0.580 to 0.567, 0.696, and 0.618, respectively. For 15-round SIMECK32/64, 19-round SIMECK48/96, and 22-round SIMECK64/128, the accuracy of their neural distinguishers is improved from 0.547, 0.516, and 0.519 to 0.568, 0.523, and 0.526, respectively.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623040 | PMC |
http://dx.doi.org/10.7717/peerj-cs.2566 | DOI Listing |
Tissue Eng Regen Med
September 2025
Department of Biomedical Science, Catholic Kwandong University, 24 Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do, South Korea.
Background: Neurotraumatic conditions, such as spinal cord injury, brain injury, and neurodegenerative conditions, such as amyotrophic lateral sclerosis, pose a challenge to the field of rehabilitation for its complexity and nuances in management. For decades, the use of cell therapy in treatment of neurorehabilitation conditions have been explored to complement the current, mainstay treatment options; however, a consensus for standardization of the cell therapy and its efficacy has not been reached in the medical community. This study aims to provide a comparative review on the very topic of cell therapy use in neurorehabilitation conditions in an attempt to bridge the gap in knowledge.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, 5735 S. Ellis Ave., SCL 123, Chicago, Illinois 60637, USA.
Molecular dynamics simulations are essential for studying complex molecular systems, but their high computational cost limits scalability. Coarse-grained (CG) models reduce this cost by simplifying the system, yet traditional approaches often fail to maintain dynamic consistency, compromising their reliability in kinetics-driven processes. Here, we introduce an adversarial training framework that aligns CG trajectory ensembles with all-atom (AA) reference dynamics, ensuring both thermodynamic and kinetic fidelity.
View Article and Find Full Text PDFAdv Mater
September 2025
State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.
Regulating the differentiation of implanted stem cells into neurons is crucial for stem cell therapy of traumatic brain injury (TBI). However, due to the migratory nature of implanted stem cells, precise and targeted regulation of their fate remains challenging. Here, neural stem cells (NSCs) are bio-orthogonally engineered with hyaluronic acid methacryloyl (HAMA) microsatellites capable of sustained release of differentiation modulators for targeted regulation of their neuronal differentiation and advanced TBI repair.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Bioengineering, Yildiz Technical University, Istanbul, 34722, Turkey.
Conductive nanocomposite hydrogels (CNHs) represent a promising tool in neural tissue engineering, offering tailored electroactive microenvironments to address the complex challenges of neural repair. This systematic scoping review, conducted in accordance with PRISMA-ScR guidelines, synthesizes recent advancements in CNH design, functionality, and therapeutic efficacy for central and peripheral nervous system (CNS and PNS) applications. The analysis of 125 studies reveals a growing emphasis on multifunctional materials, with carbon-based nanomaterials (CNTs, graphene derivatives; 36.
View Article and Find Full Text PDFBrain
September 2025
Okinawa Institute of Science and Technology Graduate University, Okinawa, 904-0495, Japan.
Animal models of the pathology of Parkinson's disease (PD) have provided most of the treatments to date, but the disease is restricted to human patients. In vitro models using human pluripotent stem cells (hPSCs)-derived neural organoids have provided improved access to study PD etiology. This study established a method to generate human striatal-midbrain assembloids (hSMAs) from hPSCs for modeling alpha-synuclein (α-syn) propagation and recapitulating basal ganglia circuits, including nigrostriatal and striatonigral pathways.
View Article and Find Full Text PDF