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Background: The concept of on-track versus off-track bone lesions in glenohumeral instability continues to evolve. Although much has been ascertained from an original biomechanical model, bony pathological changes, especially on 3-dimensional (3D) imaging, have not been fully evaluated.
Purpose: To compare the differences in on-track versus off-track lesions to characterize glenoid and humeral head bone defects using 3D modeling software.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: A consecutive cohort of 75 patients with recurrent anterior instability, with evidence of Hill-Sachs lesions (HSLs) and glenoid bone loss (GBL) and a mean age of 27.1 years (range, 18-48 years), were reviewed. 3D models of unilateral proximal humeri and glenoids were reconstructed. The volume, surface area, width, and depth of identified HSLs were quantified, along with their location (medial, superior) and orientation (Hill-Sachs angle). The percentage, width, and length of GBL as well as the glenoid track status were calculated. The on-track and off-track groups were compared using the Mann-Whitney test.
Results: The off-track group had greater HSL surface area (374.23 vs 272.64 mm, respectively; = .001), more HSL medialization (14.96 vs 17.62 mm, respectively; = .028), greater HSL volume (603.08 vs 433.61 mm, respectively; = .007), and a greater mean HSL width (16.06 vs 11.53 mm, respectively; = .001) than the on-track group. The off-track group also had greater GBL (22.55% vs 17.73%, respectively; = .037), a greater GBL width (6.92 vs 3.58 mm, respectively; < .001), and a greater GBL length (21.61 vs 16.1mm, respectively; = .015) than the on-track group. Further analysis of large off-track lesions revealed a greater Hill-Sachs angle (33.16° vs 26.20°, respectively; = .035) and a more superior extent of HSLs compared with borderline off-track and on-track lesions.
Conclusion: Off-track lesions were found to have larger GBL, a larger HSL width, a more medialized HSL, and greater HSL surface area. This study outlines the specific characteristics of high-risk bipolar bone loss lesions to simplify the identification of patients in a clinical setting and aid in appropriate treatment planning.
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http://dx.doi.org/10.1177/23259671241297071 | DOI Listing |
Chemistry
August 2025
Department of Bioproducts and Biosystems, Aalto University, Espoo, 0076 Aalto, Finland.
Directing the collective behavior of bacteria is important for various applications in chemical bioproduction, water treatment, and antibiofilm solutions. A potential approach to such control mechanisms lies in sequestering signal molecules (autoinducers) by macrocyclic host molecules that lower the effective concentration of the former, modulating bacterial signaling. Cyclodextrins (CD) - one of the best-established families of hosts - have been shown to bind homoserine lactones (HSL) acting as autoinducers, but with a focus limited to shorter (≤ 8 carbons) tailed molecules and β-CD.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
July 2025
Pan Am Clinic, Winnipeg, MB, Canada; Department of Surgery, Section of Orthopaedic Surgery, University of Manitoba, Winnipeg, MB, Canada.
Background: Arthroscopic remplissage with arthroscopic Bankart repair (ABR) may be considered for those with Hill-Sachs (HSL) and Bankart lesions. This treatment has a reported postoperative instability rate between 3.2% and 13.
View Article and Find Full Text PDFFoods
May 2025
Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
The meat quality of sheep and goats differs even within the same age, gender, and farming systems. Intramuscular fat (IMF) content is an important factor affecting the quality of livestock meat because it affects muscle color, tenderness, juiciness, water-holding capacity, and flavor. This study evaluates the differences in IMF deposition characteristics between Longdong cashmere goats and Tan sheep, and also explores the correlations between these variations and the gut microbiota.
View Article and Find Full Text PDFCirc Heart Fail
July 2025
Department of Cardiology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic (D.V., P.O.).
Background: Hemodynamic response to escalation of vasoactive drugs has not been well-characterized in patients with cardiogenic shock (CS). We tested the hypothesis that lower diastolic perfusion pressure (DPP=diastolic blood pressure-right atrial pressure) was associated with more limited hemodynamic response to uptitration of vasoactive drugs and with possible benefit from early mechanical circulatory support in patients with CS.
Methods: This study consisted of 2 parts: (1) we evaluated the relationship between baseline DPP and changes in cardiac power output index (CPOI) in response to increase in vasoactive drugs in a cohort of patients with CS (n=93) and (2) we compared all-cause mortality based on baseline DPP in a post hoc analysis of the ECMO-CS trial (Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock).
Physiology is closely synchronized to daily and seasonal light/dark cycles. Humans artificially extend daylight and experience irregular light schedules, resulting in dysregulation of metabolism and body mass. In rodents, winter-like conditions (cold and short photoperiod) can alter energy balance and adipose tissue mass.
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