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Article Abstract
In present study Wedelolactone (WL) was identified from successive extracts of whole plant (L.) L. using HPTLC, optimised extraction/isolation method and confirmed WL structure.Extraction, isolation andidentification was performed though cold-percolation method, column chromatography and TLC respectively.WL was found abundantly in ethyl acetate and ethanol extracts at UV254 & 366 nm, respectively at R0.42 by using toluene:ethyl acetate: formic acid (6:3.5:0.5, v/v/v). In the Method IV got a pure pale green crystals (0.138 g, % yield of 0.23) was adopted. Isolated compound verified by TLC and the structure confirmed by various spectroscopic tools. The study proposed high efficiency extraction-isolation method for WL, which could enhance the efficacy for identification of studying such coumestan in extracts and herbal formulations. Study potentially aiding in developing advance anti-cancer and hepatoprotectivedosages and quality control.
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