Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To investigate the relationship and potential pathways between metal(loid) exposure and the risk of polycystic ovary syndrome (PCOS) in women of childbearing age.
Methods: This case-control study included 200 patients with PCOS (cases) and 896 non-PCOS controls with the age of 25-37 years. The concentrations of 29 metal(loid)s in the follicular fluid (FF) and clinical indicators in the serum were measured in all participants. Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid) exposure and PCOS risk and investigate the possible roles of clinical indicators, respectively.
Results: Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk (highest lowest quartile: adjusted odds ratio = 2.94, 95% confidence interval: 1.83-4.72). A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone (AMH) were strongly associated with increased PCOS risk induced by high copper exposure. The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk.
Conclusion: Copper may affect PCOS risk through the hypothalamic-pituitary-ovarian axis, mediated by AMH. Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3967/bes2024.154 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.
JAMA
September 2025
Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, the Netherlands.
Importance: Pregnant individuals with polycystic ovary syndrome (PCOS) present with a higher risk of pregnancy complications, including gestational diabetes, preeclampsia, and preterm birth. Myo-inositol supplementation may reduce these risks.
Objective: To determine whether daily supplementation with myo-inositol during pregnancy among individuals with PCOS reduces the risk of a composite outcome of gestational diabetes, preeclampsia, and preterm birth.
The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study.
Int J Womens Health
September 2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
Background: Female reproductive disorders (FRDs) are common diseases among women of childbearing age, affecting their reproductive health. Age at first sexual intercourse (AFS) is potentially linked to FRDs, and this study aims to investigate these associations and underlying mechanisms, to offer new insights and guidance for sex education in adolescent women and reproductive health management.
Methods: Mendelian randomization (MR) analysis was performed using summary data from genome-wide association studies (GWASs).
Vascular imbalance in polycystic ovary syndrome: Insights into endothelial dysfunction.
PLoS One
September 2025
Department of Biostatistics, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Turkey.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder associated with vascular dysfunction and increased cardiovascular risk. This study aims to investigate the dysregulation of vascular tone in PCOS, focusing on the imbalance between vasodilators (nitric oxide [NO] and apelin) and vasoconstrictors (noradrenaline and reduced prostacyclin). By examining these factors, the study seeks to elucidate their contribution to endothelial dysfunction and cardiovascular complications in PCOS patients.
View Article and Find Full Text PDFAssociation of polycystic ovary syndrome with atherosclerotic cardiovascular disease events.
Fertil Steril
September 2025
Dept of OBGYN, University of Rochester, Rochester, NY, USA. Electronic address:
Polycystic ovary syndrome (PCOS) is a common endocrine condition often recognized for its association with reproductive complications. However, the impact of PCOS extends well beyond such that it is considered a multisystemic disorder, with effects on mental health, metabolic conditions, and pregnancy. While there is ample evidence for increased prevalence of cardiovascular disease (CVD) risk factors in PCOS including hypertension, dyslipidemia, diabetes and obesity in reproductive age and menopausal women, robust data on atherosclerotic CVD events (ASCVD), defined as coronary artery disease (CAD), myocardial infarction (MI), angina, carotid artery disease, ischemic stroke, transient ischemic attack (TIA) and peripheral artery disease (PAD), in PCOS is emerging.
View Article and Find Full Text PDFPolycystic Ovary Syndrome - Support and Prevention in Adolescence.
Geburtshilfe Frauenheilkd
September 2025
SPZ Interdisziplinär, Pädiatrische Endokrinologie und Diabetologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
For up to eight years after menarche, adolescents are in a developmental stage where PCOS (polycystic ovary syndrome) symptoms are physiological. The diagnostic criteria for PCOS in adult women therefore only partially apply. A new German S2k guideline and the international PCOS guideline of 2023 provide standardized diagnostic criteria for hyperandrogenemia and menstrual disorders in adolescence.
View Article and Find Full Text PDF