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Migraine affects 10% of adolescents and children. Typical school protocols in the USA require pharmacological medications to be administered by school nurses, often resulting in treatment delays or omissions when migraine attacks occur during school hours. The Remote Electrical Neuromodulation (REN) wearable is an FDA-cleared smartphone-controlled device delivering acute and preventive treatment of migraine attacks in patients aged 8 and above, allowing safe, effective, discreet, and independent usage. This retrospective study (NCT06180577) evaluates treatment patterns, barriers, and preferences among school-age students. REN users < 18 years old were invited to complete an online survey. Participants signed an assent form, and their parents/legal guardians signed an informed consent form. 332 patients aged 7-17 (15.5 ± 2.1) participated (80.4% female). After being prescribed the REN wearable, the percentage of students who treated their headaches at school increased from 78.3% to 89.8%. Most participants (65.4%) treated with either REN standalone (38.0%) or in combination with medications (27.4%). Common barriers to treatment included the need to leave class for the nurse's office (64.2%), concerns about standing out (42.2%), and one barrier unique to REN-permission needed to use a smartphone in class (22.9%). The most common reasons given for preferring REN treatment at school are the ability to avoid going to the nurse's office (42.5%) and to treat discreetly (39.2%). This study underscores the challenges of managing migraine at school while suggesting the importance of the REN wearable as a discreet and independently used first-line treatment for children and adolescents.
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http://dx.doi.org/10.3390/children11111286 | DOI Listing |
Adv Mater
September 2025
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Liquid crystal elastomers (LCEs) are important soft actuators that show strong promise in many fields where traditional rigid actuators or robotics are impractical. However, their real-world applications are lacking primarily due to inadequate actuation performance and complicated fabrication processes. Here, a novel design is reported that significantly enhances actuation performance while simplifying the fabrication process.
View Article and Find Full Text PDFAnal Chim Acta
October 2025
Shanghai Frontier Science Research Center for Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China. Electronic address:
Background: Blood glucose monitoring is of paramount importance for patients with diabetes. However, conventional glucose meters exhibit limited accuracy and present challenges for prolonged use, primarily due to the high consumption of glucose oxidase (GOD) and their sensitivity to temperature and environmental factors. phenylboronic acid (PBA), benefiting from its reversible reaction with glucose and superior stability, holds potential as a promising medium for long-term glucose monitoring.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, P. R. China.
Plantar wounds, particularly diabetic foot ulcers (DFUs), impose significant burdens on patients' quality of life and healthcare systems. Personalized wound management demands real-time monitoring of biomechanical parameters and effective therapeutic interventions to prevent exacerbations. Here, a dual-layer flexible liquid metal fiber (LMF) capable of simultaneous plantar pressure sensing and electrical stimulation for accelerated wound healing is presented.
View Article and Find Full Text PDFSheng Wu Yi Xue Gong Cheng Xue Za Zhi
August 2025
Physical Fitness and Health Research and Teaching Department, College of Sports Human Sciences, Beijing Sport University, Beijing 100084, P. R. China.
Exercise intervention is an important non-pharmacological intervention for various diseases, and establishing precise exercise load assessment techniques can improve the quality of exercise intervention and the efficiency of disease prevention and control. Based on data collection from wearable devices, this study conducts nonlinear optimization and empirical verification of the original "Fitness-Fatigue Model". By constructing a time-varying attenuation function and specific coefficients, this study develops an optimized mathematical model that reflects the nonlinear characteristics of training responses.
View Article and Find Full Text PDFBiomedicines
August 2025
Danube Neuroscience Research Laboratory, HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged, Tisza Lajos krt. 113, H-6725 Szeged, Hungary.
The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reveal that tryptophan (Trp) metabolism is regulated by distinct cellular "checkpoints" along the gut-brain axis, finely modulated by sex differences, circadian rhythms, and microbiome composition. However, current interventions tackle single levers in isolation, leaving a key gap in the precision control of Trp's fate.
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