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Cephalopods play a major role in marine food webs as both predators and prey. Although most of the Hg in cephalopods is present in the muscle, most studies on its accumulation by predators are based on concentrations in beaks. Here, using upper and lower beaks and buccal masses of Moroteuthopsis longimana, we evaluated the relationship between Hg concentrations in different cephalopod tissues. Hg concentrations in muscle tissue (329.9 ± 166.4 ng.g dw) were ≈100-fold higher than in different sections of the upper (3.5 ± 1.4 ng.g dw) and lower (3.5 ± 1.0 ng.g dw) beaks. A positive linear relationship was found between the Hg in the beak wing and in the muscle. Hg concentrations in the wing are therefore a useful proxy for the total Hg body burden, and their analysis provides a means of assessing the levels, transport and fate of Hg in marine ecosystems.
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http://dx.doi.org/10.1016/j.marenvres.2024.106841 | DOI Listing |
World J Urol
September 2025
Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
Purpose: To evaluate the impact of MRP inhibition by MK571 on prostate hypercontractility in diet-induced obesity, based on the hypothesis that this intervention enhances intracellular cAMP and cGMP signaling.
Methods: Adult C57BL/6 mice were divided into three groups: (i) lean, (ii) obese, and (iii) obese + MK571 (5 mg/kg/day, 14 days). The prostate was isolated for immunohistochemistry, biochemistry and functional assays.
Clin Pharmacol Drug Dev
September 2025
Phase I Clinical Research Centre, Wuhan Pulmonary Hospital, Wuhan, China.
Tamsulosin is a highly selective α1A adrenergic receptor antagonist that can relax smooth muscles in the urethra, bladder neck, and prostate and improve urinary disorders. It is therefore widely used to treat lower urinary tract symptoms caused by benign prostatic hyperplasia. The aim of this study is to evaluate the pharmacokinetic (PK) characteristics and bioequivalence of 2 different formulations (tamsulosin sustained-release tablets and tamsulosin sustained-release capsules) in healthy Chinese subjects.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:
The effects of modified atmosphere packaging (MAP) with different O and CO concentrations (M40: 40 % O/60 % CO and M80: 80 % O/20 % CO) on the bacterial community, volatile organic compounds (VOCs), color, and shelf-life of porcine longissimus muscle (LM) were investigated during 14 days of storage at 4 °C. The results indicated that the LM samples from M40 treatment exhibited significantly (P < 0.05) lower a* and L* values, as well as higher shear force values, compared to the M80 treatment.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Department of Cardiology, First Hospital of Nanping City affiliated to Fujian Medical University;
Myocardial ischemia-reperfusion injury (MIRI) endures as a substantial impediment to the management of cardiovascular disease. The pathophysiology of MIRI is complex, involving oxidative stress, calcium overload, inflammation, and apoptosis. The NRG1/ErbB4 signaling pathway has been implicated in modulating oxidative stress responses in the heart, potentially reducing cellular damage caused by free radicals.
View Article and Find Full Text PDFArch Anim Nutr
September 2025
Department Safety in the Food Chain, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Copper (Cu) supplementation is essential in pig nutrition; however, its effects on performance, trace element accumulation in edible tissues, and environmental excretion require careful evaluation. In the present study a total of 24 male, castrated fattening pigs of two different hybrid mast lines (11 weeks of age) were divided according to their initial body weight (25.8 ± 3.
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