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Objectives: Mayo Clinic's hospital-at-home program, Advanced Care at Home (ACH), launched in 2020. While hospital-at-home literature reported safe and effective care for the general patient population and those with COVID, comparative outcomes between these two groups were unknown. The aim of this retrospective analysis was to compare the outcomes of COVID and non-COVID patients enrolled in ACH and evaluate if COVID patients can be safely treated in this setting.
Methods: Demographics, clinical characteristics, and safety outcomes were retrospectively analyzed to compare COVID and non-COVID patients discharged from ACH between November 2020 and May 2022. Patient characteristics analyzed included severity of illness (SOI) and risk of mortality (ROM), calculated using All Patient Refined Diagnosis Related Groups (APR-DRG). Hospitalization-specific variables included length of stay (LOS), escalation of care, and 30-day readmission rates.
Results: Of 1051 patients, 173 (16%) had COVID, and 878 (84%) were non-COVID patients. The average age in the COVID cohort was 66.6 (15.3) years, compared with 72.2 (14.0) in the non-COVID cohort. Extreme SOI was higher in the COVID group (43.3% versus 17.4%), as was extreme ROM (46.2% versus 16.2%), but LOS was shorter (5.7 versus 7 days). Escalation of care (7.5% in COVID cohort versus 8.4%) and 30-day readmission outcomes (9.2% for COVID patients versus 12.9%) were not statistically different between the groups.
Conclusions: Despite higher SOI and ROM, COVID patients had shorter LOS with outcomes that were not statistically different from non-COVID patients. COVID patients can be safely and efficiently cared for in ACH.
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http://dx.doi.org/10.1097/PTS.0000000000001286 | DOI Listing |
Nurs Open
September 2025
Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Aim: The coronavirus disease 2019 (COVID-19) outbreak led to a massive influx of patients into hospitals, thus prompting the implementation of various response mechanisms to manage the surge in number of patients. During the mitigation period, hospital response mechanisms ceased and ensued a return to normal settings. However, changing hospital settings can affect nurses' work environments.
View Article and Find Full Text PDFAcute Crit Care
August 2025
National Brain Center, Iran University of Medical Sciences, Tehran, Iran.
Background: Delirium is an acute condition marked by disturbances in cognition, awareness, and attention, commonly observed in hospitalized patients due to factors such as illness severity and medication. It is particularly prevalent in intensive care unit settings, affecting up to 80% of ventilated patients. This study investigates whether coronavirus disease 2019 (COVID-19) delirium aligns with expectations of non-COVID-19 delirium incidence in other hospitalized patients and identifies unique or common factors contributing to delirium in these groups.
View Article and Find Full Text PDFBiotechnol J
September 2025
Department of Anesthesiology and Intensive Care, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Sepsis remains a major clinical challenge, often resulting in long-term physiological and immunological disturbances. This study employed high-throughput single-cell Raman spectroscopy to analyze the biochemical profiles of peripheral blood leukocytes from patients with non-COVID-19 and COVID-19-associated sepsis. Leukocytes were assessed at multiple timepoints, including the acute phase (Days 3 and 7 after sepsis onset) and late recovery phase (6 and 12 months after sepsis onset).
View Article and Find Full Text PDFSci Rep
August 2025
Department of Medical Biochemistry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, has posed a significant global public health challenge, with long-term sequelae such as post-COVID-19 syndrome continuing to burden health systems. Tobacco use, a major preventable cause of morbidity and mortality, impairs the immune response and exacerbates respiratory diseases, including COVID-19. Passive smoking, an important but often overlooked public health problem, exposes non-smokers to harmful health risks and may contribute to worse outcomes in respiratory disease.
View Article and Find Full Text PDFMedicina (Kaunas)
July 2025
Department of Thoracic Medicine, Family Medicine, Geriatric Medicine, Medical Research and Medical Education, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
: COVID-19 may have long-term adverse effects on bone health, particularly in individuals aged ≥50 years with obesity or diabetes, who are predisposed to impaired bone quality. : This retrospective cohort study used TriNetX data from 141 healthcare organizations across North America and Western Europe. Patients aged ≥50 years with overweight (body mass index 25-30 kg/m), obesity (body mass index ≥ 30 kg/m), or type 2 diabetes (T2DM) and COVID-19 (2019-2024) were propensity score-matched to non-COVID-19 controls.
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