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In this work, a nested hollow-core anti-resonant fiber (HC-ARF) with an elliptical cladding for high-power lasers for 2 µm laser transmission was proposed and theoretically investigated. The dual-layer elliptical tubes nested within the fiber enable the low-loss single-mode transmission. The finite element method (FEM) was employed to analyze and optimize the structure of fiber, with a total loss of less than 5 × 10dB/m across the wavelength range of 1920nm to 2040nm. An extremely low loss of 1.22 × 10dB/m at 1948nm was realized. A high-order mode extinction ratio (HOMER) exceeding 3 × 10 was maintained across a significant bandwidth and a size tolerance ratio under 15%. Furthermore, a low loss of 5 × 10dB/m at 1948nm with a bending radius over 15 cm was obtained, indicating high bending resistance. It was demonstrated that the proposed fiber has exceptional transmission performance for 2 µm laser transmission.
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http://dx.doi.org/10.1364/OE.528511 | DOI Listing |
Acta Biomater
January 2025
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharm
Photothermal therapy (PTT) is a promising treatment strategy for malignant tumors. Photothermal agents which can achieve efficient photothermal conversion in the NIR-II region plays crucial roles in this remedy. Here, we report one type of thermo-responsive gold nanorod vesicles USGRV-17-AAG for combined NIR-II photothermal therapy and chemotherapy of solid tumors.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
July 2023
Maastricht MultiModal Molecular Imaging (M4i) Institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.
We discuss the design, development, and evaluation of an Orbitrap/time-of-flight (TOF) mass spectrometry (MS)-based instrument with integrated UV photodissociation (UVPD) and time/mass-to-charge ratio (/)-resolved imaging for the comprehensive study of the higher-order molecular structure of macromolecular assemblies (MMAs). A bespoke TOF analyzer has been coupled to the higher-energy collisional dissociation cell of an ultrahigh mass range hybrid quadrupole-Orbitrap MS. A 193 nm excimer laser was employed to photofragment MMA ions.
View Article and Find Full Text PDFACS Biomater Sci Eng
June 2023
Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, United States.
Monitoring of extracellular matrix (ECM) microstructure is essential in studying structure-associated cellular processes, improving cellular function, and for ensuring sufficient mechanical integrity in engineered tissues. This paper describes a novel method to study the microscale alignment of the matrix in engineered tissue scaffolds (ETS) that are usually composed of a variety of biomacromolecules derived by cells. First, a trained loading function was derived from Raman spectra of highly aligned native tissue via principal component analysis (PCA), where prominent changes associated with specific Raman bands (e.
View Article and Find Full Text PDFJ Colloid Interface Sci
June 2023
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharm
Anal Chem
September 2022
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Core histones including H2A, H2B, H3, and H4 are key modulators of cellular repair, transcription, and replication within eukaryotic cells, playing vital roles in the pathogenesis of disease and cellular responses to environmental stimuli. Traditional mass spectrometry (MS)-based bottom-up and top-down proteomics allows for the comprehensive identification of proteins and of post-translational modification (PTM) harboring proteoforms. However, these methodologies have difficulties preserving near-cellular spatial distributions because they typically require laser capture microdissection (LCM) and advanced sample preparation techniques.
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