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Article Abstract
Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550424 | PMC |
| http://dx.doi.org/10.1038/s41698-024-00746-z | DOI Listing |
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