Paired electrocatalysis enabled oxidative coupling of styrenes with alkyl radicals.

Org Biomol Chem

Frontiers Science Center for Transformative Molecules (FSCTM), Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, ZhangJiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

Published: December 2024


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Article Abstract

A paired electrocatalysis strategy for intermolecular oxidative cross-dehydrocoupling between styrenes and ethers or -methylphenol derivatives using ketone as a mild oxidant is described. This approach enables the generation of Csp carbon-centered radicals through anodic oxidation, followed by reductive coupling of ketones at the cathode, ultimately yielding valuable oxidative alkylation products.

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