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Spinal medical image segmentation is critical for diagnosing and treating spinal disorders. However, ambiguity in anatomical boundaries and interfering factors in medical images often cause segmentation errors. Current deep learning models cannot fully capture the intrinsic data properties, leading to unstable feature spaces. To tackle the above problems, we propose Verdiff-Net, a novel diffusion-based segmentation framework designed to improve segmentation accuracy and stability by learning the underlying data distribution. Verdiff-Net integrates a multi-scale fusion module (MSFM) for fine feature extraction and a noise semantic adapter (NSA) to refine segmentation masks. Validated across four multi-modality spinal datasets, Verdiff-Net achieves a high Dice coefficient of 93%, demonstrating its potential for clinical applications in precision spinal surgery.
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http://dx.doi.org/10.3390/bioengineering11101031 | DOI Listing |
EMBO Mol Med
September 2025
Institute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, National Stem Cell Translational Resource Center & Ministry of Education Stem Cell Resource Center, Frontier Science Center for Stem Cell Research, School of Li
Primary microcephaly, a rare congenital condition characterized by reduced brain size, occurs due to impaired neurogenesis during brain development. Through whole-exome sequencing, we identified compound heterozygous loss-of-function mutations in CENTRIN 3 (CETN3) in a 5-year-old patient with primary microcephaly. As CETN3 has not been previously linked to microcephaly, we investigated its potential function in neurodevelopment in human pluripotent stem cell-derived cerebral organoids.
View Article and Find Full Text PDFBr J Anaesth
September 2025
Department of Anesthesiology and Pain Medicine, University of Toronto; Women's College Research Institute, Toronto, ON, Canada. Electronic address:
Neurol Res
September 2025
Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Background: Spinal Cord Injury (SCI) leads to partial or complete sensorimotor loss because of the spinal lesions caused either by trauma or any pathological conditions. Rehabilitation, one of the therapeutic methods, is considered to be a significant part of therapy supporting patients with spinal cord injury. Newer methods are being incorporated, such as repetitive Transcranial Magnetic Stimulation (rTMS), a Non-Invasive Brain Stimulation (NIBS) technique to induce changes in the residual neuronal pathways, facilitating cortical excitability and neuroplasticity.
View Article and Find Full Text PDFNeuron
September 2025
Shanghai Stomatological Hospital & School of Stomatology, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. Electronic address:
Existing treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting the need for better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during the early phase of nerve injury in mice, produces sustained analgesic effects by activating the dorsal column nucleus (DCN)-thalamic-cortical pathway, which transmits vibration, discriminative touch, and proprioception. Mechanistically, TENS selectively activates glutamatergic neurons in the DCN (DCN) via exciting Aβ low-threshold mechanoreceptors (Aβ-LTMRs) in dorsal root ganglia (DRGs).
View Article and Find Full Text PDFGlobal Spine J
September 2025
Department of Spinal Surgery, Zhucheng People's Hospital, Zhucheng, China.
Study DesignRetrospective cohort study.ObjectivesUnilateral percutaneous kyphoplasty (PKP) is widely used to treat osteoporotic vertebral compression fractures (OVCF) in elderly patients. Cement leakage is the most common complication and may cause serious consequences.
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